Anti-Apaf1 Antibody

Apaf1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Polyclonal

APAF1

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease-activating factor 1). Apaf1 binds to cytochrome c (Apaf-2) and caspase-9 (Apaf-3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf1 can also associate with caspase-4 and caspase-8. Apaf1 is ubiquitously expressed in human tissues.

Apaf1 Antibody is supplied in PBS containing 0.02% sodium azide.

1 mg/ml

Apoptotic peptidase activating factor 1

Cytoplasm

Ubiquitous. Highest levels of expression in
adult spleen and peripheral blood leukocytes, and in fetal brain,
kidney and lung. Isoform 1 is expressed in heart, kidney and
liver.