Anti-Phospho-Neuro D (S274) NEUROD1 Antibody

Primary Antibodies

39920 MW

WB 1:500-2000
IHC 1:50-300

Neurogenic differentiation factor 1

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

1 mg/ml

Acts as a transcriptional activator: mediates
transcriptional activation by binding to E box-containing promoter
consensus core sequences 5'-CANNTG-3'. Associates with the
p300/CBP transcription coactivator complex to stimulate
transcription of the secretin gene as well as the gene encoding
the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the
regulation of several cell differentiation pathways, like those
that promote the formation of early retinal ganglion cells, inner
ear sensory neurons, granule cells forming either the cerebellum
or the dentate gyrus cell layer of the hippocampus, endocrine
islet cells of the pancreas and enteroendocrine cells of the small
intestine. Together with PAX6 or SIX3, is required for the
regulation of amacrine cell fate specification. Also required for
dendrite morphogenesis and maintenance in the cerebellar cortex.
Associates with chromatin to enhancer regulatory elements in genes
encoding key transcriptional regulators of neurogenesis (By
similarity).

Boster Bio Anti-Phospho-Neuro D (S274) NEUROD1 Antibody catalog # A01038S274. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.