Anti-C/EBP-Beta (S229/182) CEBPB Antibody

Primary Antibodies

36106 MW

IHC: 1:50-1:200

CCAAT/enhancer-binding protein beta

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Important transcription factor regulating the expression
of genes involved in immune and inflammatory responses
(PubMed:1741402, PubMed:9374525, PubMed:12048245,
PubMed:18647749). Plays also a significant role in adipogenesis,
as well as in the gluconeogenic pathway, liver regeneration, and
hematopoiesis. The consensus recognition site is 5'-
T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein
interactions and post-translational protein modifications. During
early embryogenesis, plays essential and redundant functions with
CEBPA. Has a promitotic effect on many cell types such as
hepatocytes and adipocytes but has an antiproliferative effect on
T-cells by repressing MYC expression, facilitating differentiation
along the T-helper 2 lineage. Binds to regulatory regions of
several acute-phase and cytokines genes and plays a role in the
regulation of acute-phase reaction and inflammation. Plays also a
role in intracellular bacteria killing (By similarity). During
adipogenesis, is rapidly expressed and, after activation by
phosphorylation, induces CEBPA and PPARG, which turn on the series
of adipocyte genes that give rise to the adipocyte phenotype. The
delayed transactivation of the CEBPA and PPARG genes by CEBPB
appears necessary to allow mitotic clonal expansion and thereby
progression of terminal differentiation (PubMed:20829347).
Essential for female reproduction because of a critical role in
ovarian follicle development (By similarity). Restricts
osteoclastogenesis: together with NFE2L1; represses expression of
DSPP during odontoblast differentiation (By similarity).

Boster Bio Anti-C/EBP-Beta (S229/182) CEBPB Antibody catalog # A01100S229. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.