Anti-Fructose-1,6-bisphosphatase 1 FBP1 Antibody

Primary Antibodies

36842 MW

WB: 1:500-1:2000
ICC/IF: 1:50-1:200

Fructose-1, 6-bisphosphatase 1

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Catalyzes the hydrolysis of fructose 1, 6-bisphosphate to
fructose 6-phosphate in the presence of divalent cations, acting
as a rate-limiting enzyme in gluconeogenesis. Plays a role in
regulating glucose sensing and insulin secretion of pancreatic
beta-cells. Appears to modulate glycerol gluconeogenesis in liver.
Important regulator of appetite and adiposity; increased
expression of the protein in liver after nutrient excess increases
circulating satiety hormones and reduces appetite-stimulating
neuropeptides and thus seems to provide a feedback mechanism to
limit weight gain.

Expressed in pancreatic islets.