Anti-NPC2 Antibody

Primary Antibodies

16570 MW

WB: 1:500-1:2000
IHC: 1:50-1:200

NPC intracellular cholesterol transporter 2

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Intracellular cholesterol transporter which acts in
concert with NPC1 and plays an important role in the egress of
cholesterol from the endosomal/lysosomal compartment. Both NPC1
and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze
the mobilization of cholesterol within the multivesicular
environment of the late endosome (LE) to effect egress through the
limiting bilayer of the LE. NPC2 binds unesterified cholesterol
that has been released from LDLs in the lumen of the late
endosomes/lysosomes and transfers it to the cholesterol-binding
pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1
with the hydroxyl group buried in the binding pocket and is
exported from the limiting membrane of late endosomes/ lysosomes
to the ER and plasma membrane by an unknown mechanism. The
secreted form of NCP2 regulates biliary cholesterol secretion via
stimulation of ABCG5/ABCG8-mediated cholesterol transport.

Boster Bio Anti-NPC2 Antibody catalog # A01582. Tested in WB, IHC applications. This antibody reacts with Human, Mouse.