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Anti-SH2D1A Antibody

Anti-SH2D1A Antibody

Item no.	BOS-A01662
Manufacturer	Boster
Amount	100 ul
Category	Metabolism Obesity Western Blot
Format	Liquid
Applications	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Alias	SH2 domain-containing protein 1A,Duncan disease SH2-protein,Signaling lymphocytic activation molecule-associated protein,SLAM-associated protein,T-cell signal transduction molecule SAP,SH2D1A,DSHP,SAP
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Molecular Weight	14187 MW
Clonality	Polyclonal
Application Details	WB: 1:500-1:1000
Gene Name	SH2D1A
Gene Full Name	SH2 domain-containing protein 1A
Immunogen	A synthetic peptide corresponding to residues in Human SH2D1A.
Contents	Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Concentration	1 mg/ml
Protein Name	SH2 domain-containing protein 1A
Protein Function	Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84- mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.
Subcellular Localization	Cytoplasm.
Description	Boster Bio Anti-SH2D1A Antibody catalog # A01662. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Expressed at a high level in thymus and lung, with a lower level of expression in spleen and liver. Expressed in peripheral blood leukocytes, including T-lymphocytes. Tends to be expressed at lower levels in peripheral blood leukocytes in patients with rheumatoid arthritis.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-A01662-datasheet.pdf

BOS-A01662-safety-datasheet.pdf