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Anti-5HT1B/HTR1B Antibody Picoband®

Anti-5HT1B/HTR1B Antibody Picoband®

Item no.	BOS-A01826-2-10ug
Manufacturer	Boster
Amount	10 ug
Format	Lyophilized
Applications	WB, FC, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	1. Bartsch, T., Knight, Y. E., Goadsby, P. J. Activation of 5-HT(1B/1D) receptor in the periaqueductal gray inhibits nociception. Ann. Neurol. 56: 371-381, 2004. 2. Demchyshyn, L., Sunahara, R. K., Miller, K., Teitler, M., Hoffman, B. J., Kennedy, J. L., Seeman, P., Van Tol, H. H. M., Niznik, H. B. A human serotonin 1D receptor variant (5HT1D-beta) encoded by an intronless gene on chromosome 6. Proc. Nat. Acad. Sci. 89: 5522-5526, 1992. 3. Garcia-Nafria, J., Nehme, R., Edwards, P. C., Tate, C. G. Cryo-EM structure of the serotonin 5-HT(1B) receptor coupled to heterotrimeric G(o). Nature 558: 620-623, 2018.
Alias	Thy-1 membrane glycoprotein; CDw90; Thy-1 antigen; CD90; THY1
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
Observed Molecular Weight	50 kDa
Calculated Molecular weight	18080 MW
Clonality	Polyclonal
Application Details	Western blot, 0.25-0.5 ?g/ml, Human, Mouse, Rat Immunohistochemistry(Paraffin-embedded Section), 2-5 ?g/ml, Human, Mouse, Rat Flow Cytometry (Fixed), 1-3 ?g/1x10⁶ cells, Human ELISA, 0.1-0.5 ?g/ml, -
Manufacturer - Gene Name	HTR1B
Gene Full Name	Thy-1 cell surface antigen
Background	5-hydroxytryptamine receptor 1B also known as the 5-HT1B receptor is a protein that in humans is encoded by the HTR1B gene. The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs.
Immunogen	E.coli-derived human 5HT1B/HTR1B recombinant protein (Position: A35-S390).
Contents	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
Purification	Immunogen affinity purified.
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category	Neuroscience, Stem Cells, Synapse Marker, T Cells, T Lymphocytic Lineage
Protein Name	Thy-1 membrane glycoprotein
Protein Function	May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
Subcellular Localization	Cell membrane; Lipid-anchor, GPI-anchor.
Description	Boster Bio Anti-5HT1B/HTR1B Antibody Picoband® catalog # A01826-2. Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Detected adjacent to nodes of Ranvier in juxtaparanodal zones in spinal cord nerve fibers, but also in paranodal regions in some myelinated spinal cord axons (at protein level) (PubMed:11086297). Detected in the islet of Langerhans (PubMed:21483673).

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 ug

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