Anti-MEK-6 (S201) MAP2K6 Antibody

Primary Antibodies

37492 MW

WB: 1:500-1:1000
IHC: 1:50-1:200

Dual specificity mitogen-activated protein kinase kinase 6

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Dual specificity protein kinase which acts as an
essential component of the MAP kinase signal transduction pathway.
With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a
threonine and a tyrosine residue in the MAP kinases p38 MAPK11,
MAPK12, MAPK13 and MAPK14 and plays an important role in the
regulation of cellular responses to cytokines and all kinds of
stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both
essential for the activation of MAPK11 and MAPK13 induced by
environmental stress, whereas MAP2K6/MKK6 is the major MAPK11
activator in response to TNF. MAP2K6/MKK6 also phosphorylates and
activates PAK6. The p38 MAP kinase signal transduction pathway
leads to direct activation of transcription factors. Nuclear
targets of p38 MAP kinase include the transcription factors ATF2
and ELK1. Within the p38 MAPK signal transduction pathway,
MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14
activation, and is therefore required for STAT4 activation and
STAT4-regulated gene expression in response to IL-12 stimulation.
The pathway is also crucial for IL-6-induced SOCS3 expression and
down-regulation of IL-6-mediated gene induction; and for IFNG-
dependent gene transcription. Has a role in osteoclast
differentiation through NF-kappa-B transactivation by TNFSF11, and
in endochondral ossification and since SOX9 is another likely
downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates
apoptotic cell death in thymocytes. Acts also as a regulator for
melanocytes dendricity, through the modulation of Rho family
GTPases.

Boster Bio Anti-MEK-6 (S201) MAP2K6 Antibody catalog # A02011S201. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.