Anti-SP-100 Antibody

Primary Antibodies

100417 MW

WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200

Nuclear autoantigen Sp-100

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

1 mg/ml

Together with PML, this tumor suppressor is a major
constituent of the PML bodies, a subnuclear organelle involved in
a large number of physiological processes including cell growth,
differentiation and apoptosis. Functions as a transcriptional
coactivator of ETS1 and ETS2 according to PubMed:11909962. Under
certain conditions, it may also act as a corepressor of ETS1
preventing its binding to DNA according to PubMed:15247905.
Through the regulation of ETS1 it may play a role in angiogenesis,
controlling endothelial cell motility and invasion. Through
interaction with the MRN complex it may be involved in the
regulation of telomeres lengthening. May also regulate TP53-
mediated transcription and through CASP8AP2, regulate FAS-mediated
apoptosis. Also plays a role in infection by viruses, including
human cytomegalovirus and Epstein-Barr virus, through mechanisms
that may involve chromatin and/or transcriptional regulation.

Boster Bio Anti-SP-100 Antibody catalog # A02051. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human, Mouse.

Boster Bio Anti-SP-100 Antibody catalog # A02051. Tested in ELISA, IHC, WB applications. This antibody reacts with Human.