Anti-Mitofusin-1 MFN1 Antibody

Primary Antibodies

84160 MW

MFN1 antibody can be used for detection of MFN1 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunocytochemistry at 5 μg/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Mitofusin 1

Mitofusin 1 (MFN1) and the related protein MFN2 are mitochondrial membrane GTPase proteins that play a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (1, 2). MFN1 and MFN2 form homotypic and heterotypic complexes and coordinately regulate mitochondrial fusion and are essential for embryonic development (3). When ectopically expressed, MFN1 inhibits the apoptosis-associated amino-terminal conformation change in the apoptotic protein Bax but not its mitochondrial translocation, indicating that MFN1 is involved in the regulating the activation of Bax on the outer mitochondrial membrane (4).

MFN1 antibody is supplied in PBS containing 0.02% sodium azide.

1 mg/mL

Mitofusin 1

Mitochondrion outer membrane

Detected in kidney and heart (at protein
level) (PubMed:12759376). Ubiquitous (PubMed:11950885,
PubMed:12759376). Expressed at slightly higher level in kidney and
heart (PubMed:12759376). Isoform 2 may be overexpressed in some
tumors, such as lung cancers (PubMed:11751411).