Anti-LRP2 Antibody

Primary Antibodies

521958 MW

WB: 1:500-1:2000
IHC 1:50-1:200

Low-density lipoprotein receptor-related protein 2

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Multiligand endocytic receptor (By similarity). Acts
together with CUBN to mediate endocytosis of high-density
lipoproteins (By similarity). Mediates receptor-mediated uptake of
polybasic drugs such as aprotinin, aminoglycosides and polymyxin B
(By similarity). In the kidney, mediates the tubular uptake and
clearance of leptin (By similarity). Also mediates transport of
leptin across the blood-brain barrier through endocytosis at the
choroid plexus epithelium (By similarity). Endocytosis of leptin
in neuronal cells is required for hypothalamic leptin signaling
and leptin-mediated regulation of feeding and body weight (By
similarity). Mediates endocytosis and subsequent lysosomal
degradation of CST3 in kidney proximal tubule cells (By
similarity). Mediates renal uptake of 25-hydroxyvitamin D3 in
complex with the vitamin D3 transporter GC/DBP (By similarity).
Mediates renal uptake of metallothionein-bound heavy metals
(PubMed:15126248). Together with CUBN, mediates renal reabsorption
of myoglobin (By similarity). Mediates renal uptake and subsequent
lysosomal degradation of APOM (By similarity). Plays a role in
kidney selenium homeostasis by mediating renal endocytosis of
selenoprotein SEPP1 (By similarity). Mediates renal uptake of the
antiapoptotic protein BIRC5/survivin which may be important for
functional integrity of the kidney (PubMed:23825075). Mediates
renal uptake of matrix metalloproteinase MMP2 in complex with
metalloproteinase inhibitor TIMP1 (By similarity). Mediates
endocytosis of Sonic hedgehog protein N-product (ShhN), the active
product of SHH (By similarity). Also mediates ShhN transcytosis
(By similarity). In the embryonic neuroepithelium, mediates
endocytic uptake and degradation of BMP4, is required for correct
SHH localization in the ventral neural tube and plays a role in
patterning of the ventral telencephalon (By similarity). Required
at the onset of neurulation to sequester SHH on the apical surface
of neuroepithelial cells of the rostral diencephalon ventral
midline and to control PTCH1-dependent uptake and intracellular
trafficking of SHH (By similarity). During neurulation, required
in neuroepithelial cells for uptake of folate bound to the folate
receptor FOLR1 which is necessary for neural tube closure (By
similarity). In the adult brain, negatively regulates BMP
signaling in the subependymal zone which enables neurogenesis to
proceed (By similarity). In astrocytes, mediates endocytosis of
ALB which is required for the synthesis of the neurotrophic factor
oleic acid (By similarity). Involved in neurite branching (By
similarity). During optic nerve development, required for SHH-
mediated migration and proliferation of oligodendrocyte precursor
cells (By similarity). Mediates endocytic uptake and clearance of
SHH in the retinal margin which protects retinal progenitor cells
from mitogenic stimuli and keeps them quiescent (By similarity).
Plays a role in reproductive organ development by mediating uptake
in reproductive tissues of androgen and estrogen bound to the sex
hormone binding protein SHBG (By similarity). Mediates endocytosis
of angiotensin-2 (By similarity). Also mediates endocytosis of
angiotensis 1-7 (By similarity). Binds to the complex composed of
beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis
and lysosomal degradation (By similarity). Required for embryonic
heart development (By similarity). Required for normal hearing,
possibly through interaction with estrogen in the inner ear (By
similarity).

Boster Bio Anti-LRP2 Antibody catalog # A02463. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.