Anti-REST corepressor 1 RCOR1 Antibody

Primary Antibodies

53327 MW

WB: 1:500-1:2000
ICC/IF: 1:50-1:200
IP: 1:50-1:200
ChIP: 1:50-1:200

REST corepressor 1

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Essential component of the BHC complex, a corepressor
complex that represses transcription of neuron-specific genes in
non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites
by REST and acts by deacetylating and demethylating specific sites
on histones, thereby acting as a chromatin modifier. In the BHC
complex, it serves as a molecular beacon for the recruitment of
molecular machinery, including MeCP2 and SUV39H1, that imposes
silencing across a chromosomal interval. Plays a central role in
demethylation of Lys-4 of histone H3 by promoting demethylase
activity of KDM1A on core histones and nucleosomal substrates. It
also protects KDM1A from the proteasome. Component of a
RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone
deacetylase (HDAC) recruitment, a number of genes implicated in
multilineage blood cell development and controls hematopoietic
differentiation.

Boster Bio Anti-REST corepressor 1 RCOR1 Antibody catalog # A02799. Tested in WB, ICC/IF, IP, ChIP applications. This antibody reacts with Human, Mouse.