Anti-HSPA2 Antibody

Primary Antibodies

70021 MW

WB: 1:1, 000-1:2, 000
IHC: 1:50-1:200

Heat shock-related 70 kDa protein 2

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Molecular chaperone implicated in a wide variety of
cellular processes, including protection of the proteome from
stress, folding and transport of newly synthesized polypeptides,
activation of proteolysis of misfolded proteins and the formation
and dissociation of protein complexes. Plays a pivotal role in the
protein quality control system, ensuring the correct folding of
proteins, the re-folding of misfolded proteins and controlling the
targeting of proteins for subsequent degradation. This is achieved
through cycles of ATP binding, ATP hydrolysis and ADP release,
mediated by co-chaperones. The affinity for polypeptides is
regulated by its nucleotide bound state. In the ATP-bound form, it
has a low affinity for substrate proteins. However, upon
hydrolysis of the ATP to ADP, it undergoes a conformational change
that increases its affinity for substrate proteins. It goes
through repeated cycles of ATP hydrolysis and nucleotide exchange,
which permits cycles of substrate binding and release
(PubMed:26865365). Plays a role in spermatogenesis. In association
with SHCBP1L may participate in the maintenance of spindle
integrity during meiosis in male germ cells (By similarity).

Boster Bio Anti-HSPA2 Antibody catalog # A03474. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.