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Anti-POLA1 Antibody PicobandÂ®

Anti-POLA1 Antibody PicobandÂ®

Item no.	BOS-A04421-1-PE
Manufacturer	Boster
Amount	100 ug
Format	Lyophilized
Applications	WB, FC, IF, ICC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	PE
Sensitivity	>5000 cells
Citations	1. Adler, D. A., Tseng, B. Y., Wang, T. S.-F., Disteche, C. M. Physical mapping of the genes for three components of the mouse DNA replication complex: polymerase alpha to the X chromosome, primase p49 subunit to chromosome 10, and primase p58 subunit to chromosome 1. Genomics 9: 642-646, 1991. 2. Hanaoka, F., Tandai, M., Miyazawa, H., Murakami, Y., Hori, T., Yamada, M. Assignment of human DNA polymerase alpha gene (POLA) to the X chromosome. (Abstract) Cytogenet. Cell Genet. 40: 647 only, 1985. 3. Miyazawa, H., Tandai, M., Hanaoka, F., Yamada, M., Hori, T., Shimizu, K., Sekiguchi, M. Identification of a DNA segment containing the human DNA polymerase alpha gene. Biochem. Biophys. Res. Commun. 139: 637-643, 1986.
Alias	Tumor necrosis factor ligand superfamily member 18; Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL; TNFSF18; AITRL, GITRL, TL6; UNQ149/PRO175;
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	At -20Â°C for one year from date of receipt. After reconstitution, at 4Â°C for one month. It can also be aliquotted and stored frozen at -20Â°C for six months. Avoid repeated freezing and thawing.
Observed Molecular Weight	180 kDa
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.25 Î¼g/ml, Human Immunocytochemistry/Immunofluorescence, 5 Î¼g/ml, Human Flow Cytometry (Fixed), 1-3 Î¼g/1x10⁶ cells, Human ELISA, 0.1-0.5 Î¼g/ml, -
Manufacturer - Gene Name	POLA1
Gene Full Name	TNF superfamily member 18
Background	DNA polymerase alpha catalytic subunit is an enzyme that in humans is encoded by the POLA1 gene. This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication.
Immunogen	E.coli-derived human POLA1 recombinant protein (Position: E45-D1429).
Contents	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
Purification	Immunogen affinity purified.
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 Î¼g/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 Î¼g/ml.
Manufacturer - Research Category	Cancer, Cardiovascular, Cell Type Markers, Cytokines, Growth Factors, Growth Factors/Hormones, Immunology, Innate Immunity, Signal Transduction, Tags & Cell Markers, TNF Superfamily, Vasculature
Protein Function	Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).
Subcellular Localization	Cell membrane
Description	Boster Bio Anti-POLA1 Antibody Picoband® catalog # A04421-1. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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