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Anti-HELLS Antibody Picoband®

Anti-HELLS Antibody Picoband®

Item no.	BOS-A04702-1
Manufacturer	Boster
Amount	100 ug/vial
Format	Lyophilized
Applications	WB, FC, IF, ICC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
Citations	1. de Greef, J. C., Wang, J., Balog, J., den Dunnen, J. T., Frants, R. R., Straasheijm, K. R., Aytekin, C., van der Burg, M., Duprez, L., Ferster, A., Gennery, A. R., Gimelli, G., and 13 others. Mutations in ZBTB24 are associated with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2. Am. J. Hum. Genet. 88: 796-804, 2011. 2. De La Fuente, R., Baumann, C., Fan, T., Schmidtmann, A., Dobrinski, I., Muegge, K. Lsh is required for meiotic chromosome synapsis and retrotransposon silencing in female germ cells. Nature Cell Biol. 8: 1448-1454, 2006. 3. Dennis, K., Fan, T., Geiman, T., Yan, Q., Muegge, K. Lsh, a member of the SNF2 family, is required for genome-wide methylation. Genes Dev. 15: 2940-2944, 2001.
Alias	70 kDa ribosomal protein S6 kinase 1 antibody, KS6B1_HUMAN antibody, p70 alpha antibody, P70 beta 1 antibody, p70 ribosomal S6 kinase alpha antibody, p70 ribosomal S6 kinase beta 1 antibody, p70 S6 kinase alpha antibody, P70 S6 Kinase antibody, p70 S6 kinase alpha 1 antibody, p70 S6 kinase alpha 2 antibody, p70 S6K antibody, p70 S6K-alpha antibody, p70 S6KA antibody, p70(S6K) alpha antibody, p70(S6K)-alpha antibody, p70-alpha antibody, p70-S6K 1 antibody, p70-S6K antibody, P70S6K antibody, P70S6K1 antibody, p70S6Kb antibody, PS6K antibody, Ribosomal protein S6 kinase 70kDa polypeptide 1 antibody, Ribosomal protein S6 kinase beta 1 antibody, Ribosomal protein S6 kinase beta-1 antibody, Ribosomal protein S6 kinase I antibody, RPS6KB1 antibody, S6K antibody, S6K-beta-1 antibody, S6K1 antibody, Serine/threonine kinase 14 alpha antibody, Serine/threonine-protein kinase 14A antibody, STK14A antibody
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
Observed Molecular Weight	97 kDa
Calculated Molecular weight	52588 MW
Clonality	Polyclonal
Application Details	Western blot, 0.25-0.5 ?g/ml, Human, Mouse Immunocytochemistry/Immunofluorescence, 5 ?g/ml, Human Flow Cytometry (Fixed), 1-3 ?g/1x10⁶ cells, Human ELISA, 0.1-0.5 ?g/ml, -
Manufacturer - Gene Name	HELLS
Gene Full Name	Serine/threonine-protein kinase AtPK1/AtPK6
Background	Lymphoid-specific helicase (Lsh) is a member of the SNF2 helicase family of chromatin remodeling proteins that in humans is encoded by the HELLS gene. This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants encoding different isoforms have been identified.
Immunogen	E.coli-derived human HELLS recombinant protein (Position: N167-F838). Human HELLS shares 93% amino acid (aa) sequence identity with mouse HELLS.
Contents	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
Purification	Immunogen affinity purified.
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category	Signal Transduction, Signaling Pathway, Small G Proteins
Protein Name	Serine/threonine-protein kinase AtPK1/AtPK6
Protein Function	Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and required for maintenance of chromosome stability and ploidy levels through the RBR1-E2F pathway.
Subcellular Localization	Cytoplasm. Nucleus.
Description	Boster Bio Anti-HELLS Antibody Picoband® catalog # A04702-1. Tested in ELISA, IF, ICC, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Expressed in all tissues.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug/vial

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Delivery expected until 7/3/2025

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