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Anti-MIRO1/RHOT1 Antibody PicobandÂ®

Anti-MIRO1/RHOT1 Antibody PicobandÂ®

Item no.	BOS-A05928-1-Dylight550
Manufacturer	Boster
Amount	100 ug
Format	Lyophilized
Applications	WB, IF, IHC, ICC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	1. Fransson, A., Ruusala, A., Aspenstrom, P. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. J. Biol. Chem. 278: 6495-6502, 2003. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 4/11/2011.
Alias	B-cell CLL/lymphoma 9-like protein; B-cell lymphoma 9-like protein; BCL9-like protein; Protein BCL9-2; BCL9L; DLNB11
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Manufacturer - Conjugate / Tag	Dylight550
Storage Conditions	At -20Â°C for one year from date of receipt. After reconstitution, at 4Â°C for one month. It can also be aliquotted and stored frozen at -20Â°C for six months. Avoid repeated freezing and thawing.
Observed Molecular Weight	71 kDa
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.25 Î¼g/ml, Human, Mouse, Rat Immunohistochemistry(Paraffin-embedded Section), 2-5 Î¼g/ml, Human Immunocytochemistry/Immunofluorescence, 5 Î¼g/ml, Human ELISA, 0.1-0.5 Î¼g/ml, -
Manufacturer - Gene Name	RHOT1
Gene Full Name	BCL9 like
Background	Mitochondrial Rho GTPase 1 (MIRO1) is an enzyme that in humans is encoded by the RHOT1 gene on chromosome 17. The Ras homolog family member T1 (RHOT) is an atypical Rho Ca2+-binding GTPase that localizes to the mitochondria. RHOT1, the related protein RHOT2, the adaptor protein Milton, and the PTEN induced putative kinase 1 (PINK1), form a complex that is involved in axonal transport of mitochondria. Both PINK1 and Parkin target RHOT1 for phosphorylation and degradation, causing the arrest of mitochondrial motility.
Immunogen	E.coli-derived human MIRO1/RHOT1 recombinant protein (Position: Q63-A596).
Contents	Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
Purification	Immunogen affinity purified.
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 Î¼g/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 Î¼g/ml.
Manufacturer - Research Category	Cell Biology, Cell Cycle, Cell Differentiation, G Protein Signaling, Regulators, Signal Transduction, Signaling Pathway, Small G Proteins
Protein Function	Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1.
Subcellular Localization	Nucleus.
Description	Boster Bio Anti-MIRO1/RHOT1 Antibody Picoband® catalog # A05928-1. Tested in ELISA, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Expressed in breast, ductal and invasive ductal carcinomas of the breast, sporadic colorectal adenomas and carcinomas (at protein level). Expressed in fetal brain. Expressed in lung, amygdala, eye, prostate, pancreatic and prostate cancers, head and neck tumors and embryonal tumor.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 7/3/2025

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