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Anti-AMOTL2 Antibody PicobandÂ®

Anti-AMOTL2 Antibody PicobandÂ®

Item no.	BOS-A06852-Cy3
Manufacturer	Boster
Amount	100 ug
Format	Lyophilized
Applications	WB, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Cy3
Citations	1. Li, Z., Wang, Y., Zhang, M., Xu, P., Huang, H., Wu, D., Meng, A. The Amotl2 gene inhibits Wnt/B-catenin signaling and regulates embryonic development in zebrafish. J. Biol. Chem. 287: 13005-13015, 2012. 2. Wang, Y., Li, Z., Xu, P., Huang, L., Tong, J., Huang, H., Meng, A. Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis. J. Biol. Chem. 286: 41095-41104, 2011.
Alias	Angiomotin-like protein 2; Leman coiled-coil protein; LCCP; AMOTL2; KIAA0989
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20Â°C for one year from date of receipt. After reconstitution, at 4Â°C for one month. It can also be aliquotted and stored frozen at -20Â°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	95 kDa
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5Î¼g/ml ELISA, 0.1-0.5Î¼g/ml
Manufacturer - Gene Name	AMOTL2
Gene Full Name	angiomotin like 2
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Angiomotin-like protein 2 is a protein that in humans is encoded by the AMOTL2 gene. Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). It mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene.
Immunogen	E. coli-derived human AMOTL2 recombinant protein (Position: A401-Q480).
Contents	Each vial contains 4 mg Trehalose, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05 mg NaN₃.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 Î¼g/ml.
Manufacturer - Research Category	Cell Biology
Protein Function	Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.
Subcellular Localization	Recycling endosome.
Description	Boster Bio Anti-AMOTL2 Antibody Picoband® catalog # A06852. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 6/12/2025

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