Anti-Human CD71 TFRC Monoclonal Antibody Unconjugated, Flow Validated

Monoclonal Antibodies, Primary Antibodies

84871 MW

User needs to optimize the dilution ratio for this antibody.

Transferrin receptor protein 1

Human acute lymphoblastic leukaemia cells

Protein A purified

Cancer, Cancer Metabolism, Cardiovascular, Cell Type Markers, Hematopoietic Progenitors, Immunology, Lymphoid, Metabolism, Metabolism Processes, Myeloid, Neural Stem Cells, Pathways and Processes, Response To Hypoxia, Serum Proteins, Stem Cells, Surface Molecules, T Lymphocytic Lineage

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

Boster Bio Anti-Human CD71 TFRC Monoclonal Antibody Unconjugated, Flow Validated (Catalog# FC00591). Tested in Flow Cytometry application(s). This antibody reacts with Human.