Comparison

Anti-SLC2A1 Antibody Picoband® (monoclonal, 10C10) European Partner

Item no. BOS-M00163-1-10ug
Manufacturer Boster
Amount 10 ug
Format Lyophilized
Applications WB, FC, IF, IHC, ICC
Clone 10C10
Specific against Human (Homo sapiens)
Host Mouse
Isotype IgG1
Citations 1.Agus, D. B.; Gambhir, S. S.; Pardridge, W. M.; Spielholz, C.; Baselga, J.; Vera, J. C.; Golde, D. W. : Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters. J. Clin. Invest. 100: 2842-2848, 1997.
2.Heilig, C. W.; Saunders, T.; Brosius, F. C., III; Moley, K.; Heilig, K.; Baggs, R.; Guo, L.; Conner, D. : Glucose transporter-1-deficient mice exhibit impaired development and deformities that are similar to diabetic embryopathy. Proc. Nat. Acad. Sci. 100: 15613-15618, 2003.
3.Lazar, V.; Bidart, J.-M.; Caillou, B.; Mahe, C.; Lacroix, L.; Filetti, S.; Schlumberger, M. : Expression of the Na(+)/I(-) symporter gene in human thyroid tumors: a comparison study with other thyroid-specific genes. J. Clin. Endocr. Metab. 84: 3228-3234, 1999.
4.Manel, N.; Kim, F. J.; Kinet, S.; Taylor, N.; Sitbon, M.; Battini, J.-L. : The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV. Cell 115: 449-459, 2003.
Alias Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporter; SLC2A1; GLUT1
Available
Manufacturer - Category
Primary Antibodies
Manufacturer - Isotype
Mouse IgG1
Storage Conditions
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
55 kDa
Calculated Molecular weight
46659 MW
Clonality
Monoclonal
Application Details
Western blot, 0.1-0.5?g/ml

Immunohistochemistry (Paraffin-embedded Section), 0.5-1?g/ml

Immunocytochemistry/Immunofluorescence, 5?g/ml

Flow Cytometry (Fixed), 1-3?g/1x106 cells
Manufacturer - Gene Name
SLC2A1
Gene Full Name
solute carrier family 2 (facilitated glucose transporter), member 1
Manufacturer - Specificity
No cross reactivity with other proteins.
Background
GLUT1, also known as SLC2A1, is a major glucose transporter in the mammalian blood-brain barrier whose gene is mapped to 1p35-p31.3 and contains 10 exons. It is present at high levels in primate erythrocytes and brain endothelial cells. Not only can transport dehydroascorbic acid (the oxidized form of vitamin C) into the brain, GLUT1 is also likely to contribute to HTLV-associated disorders through interacting with HTLV envelope glycoproteins. Functionally, GLUT1 deficiency causes a decrease in embryonic glucose uptake and apoptosis, which may be involved in diabetic embryopathy, by contrast, an increased expression of GLUT1 in some malignant tumors may suggest a role for glucose-derivative tracers to detect in vivo thyroid cancer metastases by positron-emission tomography scanning.
Immunogen
E.coli-derived human SLC2A1 recombinant protein (Position: R92-V492). Human SLC2A1 shares 98% and 98.3% amino acid (aa) sequence identity with mouse and rat SLC2A1, respectively.
Contents
Each vial contains 4 mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3.
Purification
Immunogen affinity purified.
Reconstitution
Add 0.2 ml of distilled water will yield a concentration of 500 µg/ml.
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category
Channels, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Plasma Membrane, Signal Transduction
Protein Name
Isocitrate dehydrogenase [NADP] cytoplasmic
Protein Function
Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.
Subcellular Localization
Cell membrane. Multi-pass membrane protein. Melanosome.
Description
Boster Bio Anti-SLC2A1 Antibody Picoband® (monoclonal, 10C10) catalog # M00163-1. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity
Detected in erythrocytes (at protein level). Expressed at variable levels in many human tissues.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 10 ug
Available: In stock
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