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Anti-Lamin B1/LMNB1 Antibody PicobandÂ®

Anti-Lamin B1/LMNB1 Antibody PicobandÂ®

Item no.	BOS-PA1048-carrier-free
Manufacturer	Boster
Amount	100 ug
Format	Lyophilized
Applications	WB, IF, IHC, ICC, IHC-F
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Sensitivity	<10pg/ml
Citations	1. Pollard, K. M.; Chan, E. K.; Grant, B. J.; Sullivan, K. E.; Tan, E. M.; Glass, C. A. : In vitro posttranslational modification of lamin B clones from a human T-cell line. Molec. Cell. Biol. 10: 2164-2175, 1990 2. Tsai, M.-Y.; Wang, S.; Heidinger, J. M.; Shumaker, D. K.; Adam, S. A.; Goldman, R. D.; Zheng, Y. : A mitotic lamin B matrix induced by RanGTP required for spindle assembly. Science 311: 1887-1893, 2006.
Alias	Lamin-B1;LMNB1;LMN2, LMNB;
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Manufacturer - Conjugate / Tag	carrier-free
Storage Conditions	Store at -20Â°C for one year from date of receipt. After reconstitution, at 4Â°C for one month. It can also be aliquotted and stored frozen at -20Â°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	70 kDa
Calculated Molecular weight	66408 MW
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5Î¼g/ml, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1Î¼g/ml, Human, Rat, By Heat Immunohistochemistry (Frozen Section), 0.5-1Î¼g/ml, Rat Immunocytochemistry , 0.5-1Î¼g/ml, Human Immunocytochemistry/Immunofluorescence, 5 Î¼g/ml, Human
Manufacturer - Gene Name	LMNB1
Gene Full Name	Lamin-B1
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene. The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are though to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human Lamin B1, different from the related rat sequence by one amino acid, and from the related mouse sequence by three amino acids.
Contents	Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 Î¼g/ml.
Manufacturer - Research Category	Apoptosis, Cancer, Cell Biology, Cell Death, Cytoskeleton, Cytoskeleton/ECM, Intermediate Filaments, Nucleus, Signal Transduction, Subcellular Markers, Tags & Cell Markers
Protein Name	Lamin-B1
Protein Function	Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Subcellular Localization	Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side.
Description	Boster Bio Anti-Lamin B1/LMNB1 Antibody catalog # PA1048. Tested in IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Widely expressed in non-excitable tissues.
Sequence Similarities	Belongs to the intermediate filament family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 6/12/2025

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