Item no. |
BOS-PA1436-Cy3 |
Manufacturer |
Boster
|
Amount |
100 ug |
Format |
Lyophilized |
Applications |
WB, IHC |
Specific against |
Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus) |
Host |
Rabbit |
Isotype |
IgG |
Conjugate/Tag |
Cy3 |
Sensitivity |
<10pg/ml |
Citations |
1. Davies, A. A., Moss, S. E., Crompton, M. R., Jones, T. A., Spurr, N. K., Sheer, D., Kozak, C., Crumpton, M. J.The gene coding for the p68 calcium-binding protein is localized to bands q32-q34 of human chromosome 5, and to mouse chromosome 11.Hum. Genet. 82: 234-238, 1989. 2. Smith, P. D., Davies, A., Crumpton, M. J., Moss, S. E.Structure of the human annexin VI gene.Proc. Nat. Acad. Sci. 91: 2713-2717, 1994. 3. Thomas, D. D. H., Kaspar, K. M., Taft, W. B., Weng, N., Rodenkirch, L. A., Groblewski, G. E.Identification of annexin VI as a Ca(2+)-sensitive CRHSP-28-binding protein in pancreatic acinar cells.J. Biol. Chem. 277: 35496-35502, 2002. |
Alias |
Annexin A6;67 kDa calelectrin;Annexin VI;Annexin-6;Calphobindin-II;CPB-II;Chromobindin-20;Lipocortin VI;Protein III;p68;p70;ANXA6;ANX6; |
Available |
|
Manufacturer - Category |
Primary Antibodies |
Manufacturer - Isotype |
Rabbit IgG |
Storage Conditions |
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. |
Observed Molecular Weight |
45 kDa |
Calculated Molecular weight |
75873 MW |
Clonality |
Polyclonal |
Application Details |
Immunohistochemistry (Frozen Section), 0.5-1μg/ml, Rat, Human, Mouse Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Rat, Mouse, By Heat Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse |
Manufacturer - Gene Name |
ANXA6 |
Gene Full Name |
Annexin A6 |
Manufacturer - Specificity |
No cross reactivity with other proteins. |
Background |
Annexin A6 (ANXA6) is a member of a family of proteins that bind membrane or cytoskeleton in a Ca (2+)-dependent manner. These proteins are characterized by homologous amino acid sequences that are present in multiple copies in each protein. ANXA6 gene is assigned to 5q32-q34 by use of a cDNA clone to probe genomic DNA from rodent-human somatic cell hybrids and for in situ hybridization.The ANX6 gene is approximately 60 kb long and contains 26 exons. The genomic sequence at the 3-prime end does not contain a canonical polyadenylylation signal.Ca (2+)-dependent binding between CRHSP28 and ANXA6 is required for acinar cell membrane trafficking events and digestive enzyme secretion |
Immunogen |
A synthetic peptide corresponding to a sequence at the C-terminus of human Annexin VI, identical to the related mouse and rat sequences. |
Contents |
Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3. |
Purification |
Immunogen affinity purified. |
Reconstitution |
Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml. |
Concentration |
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml. |
Manufacturer - Research Category |
Signal Transduction, Signaling Pathway |
Protein Name |
Annexin A6 |
Protein Function |
May associate with CD21. May regulate the release of Ca (2+) from intracellular stores. |
Subcellular Localization |
Cytoplasm. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
Description |
Boster Bio Anti-Annexin VI/ANXA6 Antibody catalog # PA1436. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. |
Sequence Similarities |
Belongs to the annexin family. |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.