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Anti-GDNF Antibody Picoband®

Anti-GDNF Antibody Picoband®

Item no.	BOS-PB9069-carrier-free
Manufacturer	Boster
Amount	100 ug
Format	Lyophilized
Applications	WB
Specific against	Human (Homo sapiens), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Sensitivity	<5pg/ml
Citations	1. Lin, L.-F. H.; Doherty, D. H.; Lile, J. D.; Bektesh, S.; Collins, F. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260: 1130-1132, 1993. 2. Bermingham, N.; Hillermann, R.; Gilmour, F.; Martin, J. E.; Fisher, E. M. Human glial cell line-derived neurotrophic factor (GDNF) maps to chromosome 5. Hum. Genet. 96: 671-673, 1995. 3. Durbec, P.; Marcos-Gutierrez, C. V.; Kilkenny, C.; Grigoriou, M.; Wartiowaara, K.; Suvanto, P.; Smith, D.; Ponder, B.; Costantini, F.; Saarma, M.; Sariola, H.; Pachnis, V. GDNF signalling through the Ret receptor tyrosine kinase. Nature 381: 789-793, 1996.
Alias	Glial cell line-derived neurotrophic factor;hGDNF;Astrocyte-derived trophic factor;ATF;GDNF;
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Manufacturer - Conjugate / Tag	carrier-free
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	24 kDa
Calculated Molecular weight	23720 MW
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5μg/ml, Rat, Human
Manufacturer - Gene Name	GDNF
Gene Full Name	Glial cell line-derived neurotrophic factor
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Glial cell line-derived neurotrophic factor (GDNF) is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily. GDNF is also a potent neurotrophic factor that promotes the survival of dopaminergic neurones in cultures including embryonic neuronal cultures. In addition to its potential role in the differentiation and survival of central nervous system neurons, it has profound effects on kidney organogenesis and the development of the peripheral nervous system. GDNF may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons.
Immunogen	E.coli-derived human GDNF recombinant protein (Position: S78-I211). Human GDNF shares 93% amino acid (aa) sequence identity with both mouse and rat GDNF.
Contents	Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Developmental Biology, Growth and Development, Neurodegenerative Disease, Neurology Process, Neuroscience, Organogenesis
Protein Name	Glial cell line-derived neurotrophic factor
Protein Function	Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
Subcellular Localization	Secreted.
Description	Boster Bio Anti-GDNF Antibody Picoband® catalog # PB9069. Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change.
Sequence Similarities	Belongs to the TGF-beta family. GDNF subfamily.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-PB9069-carrier-free-datasheet.pdf

BOS-PB9069-carrier-free-safety-datasheet.pdf