Comparison

Anti-Cytokeratin 19/KRT19 Antibody Picoband® European Partner

Item no. BOS-PA1335
Manufacturer Boster
Amount 100 ug/vial
Category
Type Antibody Polyclonal
Format Lyophilized
Applications WB, IHC, ICC
Specific against Human (Homo sapiens)
Host Rabbit
Isotype IgG
Sensitivity >5000 cells
Citations 1. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74.
2. "Entrez Gene: KRT19 keratin 19".
3. W. Jeffrey Allard, Jeri Matera, M. Craig Miller, et al. (October 2004). "Tumor Cells Circulate in the Peripheral Blood of All Major Carcinomas but not in Healthy Subjects or Patients With Nonmalignant Diseases". Clin. Cancer Research 10 (20): 6897–6904.
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Keratin, type I cytoskeletal 19;Cytokeratin-19;CK-19;Keratin-19;K19;KRT19;
Similar products Keratin, type I, 40 kDa keratin intermediate filament antibody, CK 19 antibody, CK-19 antibody, ck19 antibody, Cytokeratin 19 antibody, Cytokeratin-19 antibody, k19 antibody, K1C19_HUMAN antibody, k1cs antibody, Keratin 19 antibody, Keratin type I 40 kD antibody, Keratin type I 40kD antibody, Keratin type I cytoskeletal 19 antibody, type I cytoskeletal 19 antibody, 40 kd antibody, Keratin-19 antibody, krt19 antibody, mgc15366 antibody
Available
Manufacturer - Category
Primary Antibodies
Manufacturer - Isotype
Rabbit IgG
Storage Conditions
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
44 kDa
Calculated Molecular weight
44106 MW
Clonality
Polyclonal
Application Details
Immunocytochemistry , 0.5-1?g/ml, Human, -
Immunohistochemistry (Frozen Section), 0.5-1?g/ml, Human, -
Immunohistochemistry (Paraffin-embedded Section), 0.5-1?g/ml, Human, By Heat
Western blot, 0.1-0.5?g/ml, Human
Manufacturer - Gene Name
KRT19
Gene Full Name
Keratin, type I cytoskeletal 19
Manufacturer - Specificity
No cross reactivity with other proteins.
Background
Keratin, type I cytoskeletal 19 is a protein that in humans is encoded by the KRT19 gene.The protein encoded by this gene is a member of the keratin family. It is specifically expressed in the periderm, the transiently superficial layer that envelops the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. Due to its high sensitivity, KRT19 is the most used marker for the RT-PCR-mediated detection of tumor cells disseminated in lymph nodes, peripheral blood, and bone marrow of breast cancer patients.Keratin 19 is often used together with keratin 8 and keratin 18 to differentiate cells of epithelial origin from hematopoietic cells in tests that enumerate circulating tumor cells in blood.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Cytokeratin 19.
Contents
Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
Purification
Immunogen affinity purified.
Reconstitution
Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category
Class I, Cytoskeleton, Cytoskeleton/ECM, Intermediate Filaments, Signal Transduction
Protein Name
Keratin, type I cytoskeletal 19
Protein Function
Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
Subcellular Localization
Membrane; Single-pass type I membrane protein.
Description
Boster Bio Anti-Cytokeratin 19/KRT19 Antibody catalog # PA1335. Tested in IHC, ICC, WB applications. This antibody reacts with Human.
Tissue Specificity
Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.
Sequence Similarities
Belongs to the CD34 family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ug/vial
Available: In stock
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