Anti-Connexin 43/GJA1 Antibody Picoband®

Primary Antibodies

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

43008 MW

Immunohistochemistry (Frozen Section), 0.5-1?g/ml
Immunohistochemistry (Paraffin-embedded Section), 0.5-1?g/ml
Western blot, 0.1-0.5?g/ml

Gap junction alpha-1 protein

Connexins 43 (Cx43), also called GAP Junction Protein, alpha-1 (GJA1). Connexin 43 is a member of the connexin gene family which abundantly expressed in the heart and liver and was mapped to 6q21-q23.2. Connexin43, the major protein of gap junctions in the heart, is targeted by several protein kinases that regulate myocardial cell-cell coupling. Mutations in the connexin43 gap-junction gene, which lead to abnormally regulated cell-cell communication, are associated with visceroatrial heterotaxia. Cx43 must also play a critical role in the physiology of hearing, presumably by participating in the recycling of potassium to the cochlear endolymph.

Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg Thimerosal, 0.01mg NaN3.

Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.

Atherosclerosis, Cardiovascular, Cell Adhesion, Cytoskeleton/ECM, Signal Transduction, Vascular Inflammation

Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity).

Boster Bio Anti-Connexin 43/GJA1 Antibody catalog # PA1026-1. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.

Belongs to the connexin family. Alpha-type (group II) subfamily.