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Anti-SMAD2/3 Antibody

Anti-SMAD2/3 Antibody

Item no.	BOS-PA1073-2
Manufacturer	Boster
Amount	100 ug/vial
Category	Oncology Neuroscience Neural Lineage Markers Targets for Rodent Neurosciences Antibodies Primary Antibodies By Organ Colorectal Cancer Neurodegeneration Markers
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	1. Riggins G.J., Thiagalingam S., Rosenblum E., Weinstein C.L., Kern S.E., Hamilton S.R., Willson J.K.V., Markowitz S.D., Kinzler K.W., Vogelstein B.V.;"Mad-related genes in the human."; Nat. Genet. 13:347-349(1996). 2. Zhang Y., Feng X.-H., Wu R.-Y., Derynck R.;"Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.";Nature 383:168-172(1996). 3. Inman, G. J.; Nicolas, F. J.; Hill, C. S. : Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity. Molec. Cell 10: 283-294, 2002.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Specificity	No cross reactivity with other proteins.
Storage Conditions	At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for a longer time. Avoid repeated freezing and thawing.
Manufacturer - Gene Name	SMAD2/3
Gene Full Name	SMAD family member 2/3
Background	SMAD proteins transmit signals from transmembrane serine/threonine kinase receptors to the nucleus. Transforming growth factor (TGF)-beta stimulation leads to phosphorylation and activation of Smad2 and Smad3, which form complexes with Smad4 that accumulate in the nucleus and regulate transcription of target genes. Smad2 and Smad3 share highly homology. SMAD2/SMAD3 signal transduction appeared to be important in the regulation of muscle-specific genes. SMAD proteins transmit signals from transmembrane serine/threonine kinase receptors to the nucleus. Smad2 is a 58 kDa member of a family of proteins involved in cell proliferation, differentiation and development.Smad3 is a 50 kDa member of a family of proteins that act as key mediators of TGF beta superfamily signaling in cell proliferation, differentiation and development.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human SMAD2/3(358-374 QSPNCNQRYGWHPATVC), identical to the related mouse and rat sequences.
Contents	Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Protein Name	Mothers against decapentaplegic homolog 2/3

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-PA1073-2-datasheet.pdf

BOS-PA1073-2-safety-datasheet.pdf