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Anti-Canstatin Antibody Picoband®

Anti-Canstatin Antibody Picoband®

Item no.	BOS-PA1521
Manufacturer	Boster
Amount	100 ug/vial
Category	Neuroscience Protein Aggregation, Clearance & Misfolding Antibodies Cell Biology Cell Movement Cell Adhesion Immunohistochemistry Western Blot Immunocytochemistry Cell Stainings ECM Primary Antibodies
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB, IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Sensitivity	<15pg/ml
Citations	1. Hwang-Bo J, Hyun Yoo K, Park JH, Jeong HS, Chung IS.:Recombinant canstatin inhibits angiopoietin-1-induced angiogenesis and lymphangiogenesis. Int J Cancer. 2011 Aug 5. 2. Hwang-Bo J, Yoo KH, Jeong HS, Chung IS.Recombinant canstatin inhibits tumor growth in an orthotopic AT-84 oral squamous cell carcinoma model. Biotechnol Lett. 2010 Feb;32(2):189-94. Epub 2009 Oct 17.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Collagen alpha-2 (IV) chain;Canstatin;COL4A2;
Similar products	Arresten antibody, Canstatin antibody, CO4A1_HUMAN antibody, COL4A1 antibody, COL4A1 NC1 domain antibody, Collagen Alpha 1(IV) Chain antibody, collagen alpha-1(IV) chain antibody, Collagen IV Alpha 1 Polypeptide antibody, Collagen Of Basement Membrane Alpha 1 Chain antibody, Collagen Type IV Alpha 1 antibody, DKFZp686I14213 antibody, FLJ22259 antibody, COL4A2 antibody, COL4A3 antibody, COL4A4 antibody, COL4A5 antibody, Collagen Alpha 2(IV) Chain antibody, Collagen IV Alpha 2 Polypeptide antibody, Collagen Of Basement Membrane Alpha 2 Chain antibody, Collagen Type IV Alpha 2 antibody, Collagen Type IV Alpha 3 antibody, Collagen Type IV Alpha 4 antibody, Collagen Type IV Alpha 5 antibody
Available
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	56 kDa
Calculated Molecular weight	24 kDa
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5?g/ml, Human Immunohistochemistry (Paraffin-embedded Section), 2-5?g/ml, Human, By Heat
Manufacturer - Gene Name	COL4A2
Gene Full Name	Collagen alpha-2(IV) chain
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Canstatin, a cleavage product corresponding to the collagen alpha 2 (IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human Canstatin, identical to the related rat and mouse sequences.
Contents	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category	Angiogenesis, Cardiovascular, Collagen, Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Signal Transduction
Protein Name	Canstatin
Protein Function	Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins.
Subcellular Localization	Secreted, extracellular space, extracellular matrix, basement membrane.
Description	Boster Bio Anti-Canstatin Antibody catalog # PA1521. Tested in IHC, WB applications. This antibody reacts with Human.
Tissue Specificity	Widely expressed. Differentially expressed in various brain regions.
Sequence Similarities	Belongs to the type IV collagen family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-PA1521-datasheet.pdf

BOS-PA1521-safety-datasheet.pdf