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Anti-eNOS/NOS3 Antibody

Anti-eNOS/NOS3 Antibody

Item no.	BOS-PA1712-1
Manufacturer	Boster
Amount	100 ug/vial
Category	Oncology Neuroscience Metabolism Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Antibodies Primary Antibodies By Organ Skin Cancer Testicular & Prostate Cancer
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	1. Ahsan, A., Norboo, T., Baig, M. A., Pasha, M. A. Q. Simultaneous selection of the wild-type genotypes of the G894T and 4B/4A polymorphisms of NOS3 associate with high-altitude adaptation. Ann. Hum. Genet. 69: 260-267, 2005. 2. Chen, C.-A., Wang, T.-Y., Varadharaj, S., Reyes, L. A., Hemann, C., Talukder, M. A. H., Chen, Y.-R., Druhan, L. J., Zweier, J. L. S-glutathionylation uncouples eNOS and regulates its cellular and vascular function. Nature 468: 1115-1118, 2010. 3. Fulton, D., Gratton, J.-P., McCabe, T. J., Fontana, J., Fujio, Y., Walsh, K., Franke, T. F., Papapetropoulos, A., Sessa, W. C. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399: 597-601, 1999.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	cNOS antibody, Constitutive NOS antibody, EC NOS antibody, EC-NOS antibody, ecNOS antibody, Endothelial nitric oxidase synthase antibody, Endothelial nitric oxide synthase antibody, Endothelial nitric oxide synthase 3 antibody, Endothelial NOS antibody, eNOS antibody, Nitric oxide synthase 3(endothelial cell) antibody, Nitric oxide synthase 3 antibody, Nitric oxide synthase 3 endothelial cell antibody, Nitric oxide synthase endothelial antibody, Nitric oxide synthase, endothelial antibody, NOS 3 antibody, NOS III antibody, NOS type III antibody, NOS3 antibody, NOS3_HUMAN antibody, NOSIII antibody
Similar products	Nitric oxide synthase, Constitutive NOS antibody, cNOS antibody, EC NOS antibody, EC-NOS antibody, ecNOS antibody, Endothelial nitric oxidase synthase antibody, Endothelial nitric oxide synthase antibody, Endothelial nitric oxide synthase 3 antibody, Endothelial NOS antibody, eNOS antibody, Nitric oxide synthase 3(endothelial cell) antibody, Nitric oxide synthase 3 antibody, Nitric oxide synthase 3 endothelial cell antibody, Nitric oxide synthase endothelial antibody, endothelial antibody, NOS 3 antibody, NOS III antibody, NOS type III antibody, NOS3 antibody, NOS3_HUMAN antibody, NOSIII antibody
Available
Specificity	No cross reactivity with other proteins.
Storage Conditions	At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for a longer time. Avoid repeated freezing and thawing.
Manufacturer - Gene Name	NOS3
Gene Full Name	DNA replication licensing factor MCM2
Background	NOS3(Nitric Oxide Synthase 3), also called ENOS, a nitric oxide synthase that generates NO in blood vessels and is involved with regulating vascular tone by inhibiting smooth muscle contraction andplatelet aggregation. The NOS3 gene is mapped on 7q36.1. Variations in this gene are associated with susceptibility to coronary spasm. Fulton et al.(1999) concluded the eNOS is an AKT substrate linking signal transduction by AKT to the release of the gaseous second messenger nitric oxide. AKT mediates the activation of eNOS, leading to increased nitric oxide production. Inhibition of the PI3K AKT pathway or mutation of the AKT site on eNOS protein at serine-1177 attenuated the serine phosphorylation and prevented the activation of eNOS. RT-PCR analysis showed that expression of NOS3 in human umbilical vein endothelial cells(HUVECs) and human aortic vascular smooth muscle cells(HAOVSMCs) was inversely proportional to that of NOS3AS.
Immunogen	A synthetic peptide corresponding to a sequence at the N-terminus of human eNOS(144-165 QAHEQRLQEVEAEVAATGTYQL), identical to the related mouse sequence, and different from the related rat sequence by one sequence.
Contents	Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Protein Name	Nitric oxide synthase, endothelial

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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BOS-PA1712-1-datasheet.pdf

BOS-PA1712-1-safety-datasheet.pdf