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Anti-CD11b/ITGAM Antibody Picoband®

Anti-CD11b/ITGAM Antibody Picoband®

Item no.	BOS-PB9140
Manufacturer	Boster
Amount	100 ug/vial
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Aging & Neurological Disorders Neural Adhesion Molecules Antibodies Cell Biology Cell Movement Cell Adhesion Immunohistochemistry Western Blot Primary Antibodies By Organ Skin Cancer Oligodendrocyte Markers
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB, FC, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Sensitivity	<5pg/ml
Citations	1. Arnaout, M. A., Remold-O'Donnell, E., Pierce, M. W., Harris, P., Tenen, D. G. Molecular cloning of the alpha-subunit of human and guinea pig leukocyte adhesion glycoprotein Mo1: chromosomal localization and homology to the alpha-subunits of integrins. Proc. Nat. Acad. Sci. 85: 2776-2780, 1988. 2. Solovjov D, Pluskota E, Plow E (2005). "Distinct roles for the alpha and beta subunits in the functions of integrin alphaMbeta2". J Biol Chem 280 (2): 1336–45. 3. Simon, D. I., Chen, Z., Seifert, P., Edelman, E. R., Ballantyne, C. M., Rogers, C. Decreased neointimal formation in Mac-1 -/- mice reveals a role for inflammation in vascular repair after angioplasty. J. Clin. Invest. 105: 293-300, 2000.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Integrin alpha-M;CD11 antigen-like family member B;CR-3 alpha chain;Cell surface glycoprotein MAC-1 subunit alpha;Leukocyte adhesion receptor MO1;Neutrophil adherence receptor;CD11b;ITGAM;CD11B, CR3A;
Similar products	CD49d antibody, MAC 1 antibody, MAC1 antibody, alpha subunit antibody, Antigen CD11b p170 antibody, CD11 antigen like family member B antibody, CD11 antigen-like family member B antibody, CD11b antibody, CD11b/CD18 antibody, Cell surface glycoprotein MAC-1 subunit alpha antibody, Complement component 3 receptor 3 subunit antibody, Complement Component Receptor 3 Alpha antibody, Complement receptor type 3, CR 3 alpha chain antibody, CR-3 alpha chain antibody, CR3 antibody, CR3A antibody, F730045J24Rik antibody, Integrin Alpha M antibody, Integrin alpha M chain antibody, Integrin alpha-M antibody, Integrin beta 2 alpha subunit antibody, ITAM_HUMAN antibody, ITGAM antibody, Ly-40 antibody, Mac-1a antibody, Mac1, MAC1A antibody, Macrophage antigen alpha polypeptide antibody, MGC117044 antibody, Mo1, MO1A antibody, Neutrophil adherence receptor alpha M subunit antibody, SLEB6 antibody, Leukocyte adhesion receptor MO1 antibody, Neutrophil adherence receptor antibody
Available
Specificity	No cross reactivity with other proteins.
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	45 kDa
Calculated Molecular weight	127179 MW
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5?g/ml, Human Immunohistochemistry (Paraffin-embedded Section), 0.5-1?g/ml, Human, Mouse, Rat, By Heat Flow Cytometry (Fixed), 1-3?g/1x10⁶ cells, Human
Manufacturer - Gene Name	ITGAM
Gene Full Name	Integrin alpha-M
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Integrin alpha M (ITGAM) is one protein subunit that forms the heterodimeric integrin alpha-M beta-2 (?M?2) molecule, also known as macrophage-1 antigen (Mac-1) or complement receptor 3 (CR3). It is mapped to 16p11.2. ITGAM has a role in vascular repair after mechanical arterial injury. It is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. What's more, ITGAM probably recognizes the R-G-D peptide in C3b, and it is also a receptor for fibrinogen, factor X and ICAM1.
Immunogen	E.coli-derived human CD11b recombinant protein (Position: F17-T382). Human CD11b shares 79% and 61% amino acid (aa) sequences identity with mouse and rat CD11b, respectively.
Contents	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category	Cell Adhesion, Cell Type Marker, Cell Type Markers, Cytoskeleton/ECM, Hematopoietic Progenitors, Integrins, Lymphoid, Mesenchymal Stem Cells, Myeloid, Neuroscience, Signal Transduction, Stem Cells, T Lymphocytic Lineage
Protein Name	Integrin alpha-M
Protein Function	Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Subcellular Localization	Membrane; Single-pass type I membrane protein.
Description	Boster Bio Anti-CD11b/ITGAM Antibody Picoband® catalog # PB9140. Tested in Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity	Predominantly expressed in monocytes and granulocytes.
Sequence Similarities	Belongs to the integrin alpha chain family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-PB9140-datasheet.pdf

BOS-PB9140-safety-datasheet.pdf