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Anti-Human CD11b DyLight® 550 conjugated ITGAM Antibody

Anti-Human CD11b DyLight® 550 conjugated ITGAM Antibody

Item no.	BOS-A00144-Dyl550
Manufacturer	Boster
Amount	100 ug/vial
Category	Neuroscience Neural Lineage Markers Aging & Neurological Disorders Antibodies Flow Cytometry Primary Antibodies Oligodendrocyte Markers
Type	Antibody Primary
Format	Liquid
Applications	FC
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	DyLight 550
Citations	1. Arnaout, M. A., Remold-O'Donnell, E., Pierce, M. W., Harris, P., Tenen, D. G. Molecular cloning of the alpha-subunit of human and guinea pig leukocyte adhesion glycoprotein Mo1: chromosomal localization and homology to the alpha-subunits of integrins. Proc. Nat. Acad. Sci. 85: 2776-2780, 1988. 2. Solovjov D, Pluskota E, Plow E (2005). "Distinct roles for the alpha and beta subunits in the functions of integrin alphaMbeta2". J Biol Chem 280 (2): 1336–45. 3. Simon, D. I., Chen, Z., Seifert, P., Edelman, E. R., Ballantyne, C. M., Rogers, C. Decreased neointimal formation in Mac-1 -/- mice reveals a role for inflammation in vascular repair after angioplasty. J. Clin. Invest. 105: 293-300, 2000.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD11b; ITGAM; CD11B; CR3A
Available
Specificity	No cross reactivity with other proteins.
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Observed Molecular Weight	39 kDa
Clonality	Polyclonal
Application Details	Flow Cytometry (Fixed), 1-3?g/1x10⁶ cells
Manufacturer - Gene Name	ITGAM
Gene Full Name	integrin alpha M
Manufacturer - Specificity	No cross reactivity with other proteins.
Immunogen	E. coli-derived human CD11b recombinant protein (Position: N129-E336).
Contents	Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Manufacturer - Research Category	Cell Adhesion, Cell Type Marker, Cell Type Markers, Cytoskeleton/ECM, Hematopoietic Progenitors, Integrins, Lymphoid, Mesenchymal Stem Cells, Myeloid, Neuroscience, Signal Transduction, Stem Cells, T Lymphocytic Lineage
Protein Function	Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Subcellular Localization	Membrane; Single-pass type I membrane protein.
Description	Boster Bio Anti-Human CD11b DyLight® 550 conjugated ITGAM Antibody catalog # A00144-Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.
Tissue Specificity	Predominantly expressed in monocytes and granulocytes.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-A00144-Dyl550-datasheet.pdf

BOS-A00144-Dyl550-safety-datasheet.pdf