« Back
Home /
Anti-Dysferlin Antibody

Anti-Dysferlin Antibody

Item no.	BOS-A01234-1
Manufacturer	Boster
Amount	100 ul
Category	Neuroscience Molecular Targets for Neuroscience Antibodies Western Blot Primary Antibodies
Type	Antibody
Format	Liquid
Applications	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Dysferlin;Dystrophy-associated fer-1-like protein;Fer-1-like protein 1;DYSF;FER1L1;
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	237295 MW
Clonality	Polyclonal
Application Details	Western blotting: 1:500~1:3000
Manufacturer - Gene Name	DYSF
Gene Full Name	Dysferlin
Background	Key calcium ion sensor involved in the Ca2+-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress By similarity. Delia J. Hern¨¢ndez-Deviez, Hum. Mol. Genet., Jan 2006; 15: 129 - 142. Yanchao Huang, FASEB J, Mar 2007; 21: 732 - 742. Mengfatt Ho, Hum. Mol. Genet., Sep 2004; 13: 1999 - 2010. Eriko Fujita, Hum. Mol. Genet., Mar 2007; 16: 618 - 629.
Immunogen	Synthesized peptide derived from human Dysferlin.
Contents	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration	1 mg/ml
Manufacturer - Research Category	Cell Biology
Protein Function	Key calcium ion sensor involved in the Ca (2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity).
Subcellular Localization	Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasmic vesicle membrane; Single-pass type II membrane protein. Cell membrane. Colocalizes, during muscle differentiation, with BIN1 in the T-tubule system of myotubules and at the site of contact between two myotubes or a myoblast and a myotube. Wounding of myotubes led to its focal enrichment to the site of injury and to its relocalization in a Ca (2+)-dependent manner toward the plasma membrane. Colocalizes with AHNAK, AHNAK2 and PARVB at the sarcolemma of skeletal muscle. Detected on the apical plasma membrane of the syncytiotrophoblast. Reaches the plasmma membrane through a caveolin-independent mechanism. Retained by caveolin at the plasmma membrane (By similarity). Colocalizes, during muscle differentiation, with CACNA1S in the T-tubule system of myotubules (By similarity). Accumulates and colocalizes with fusion vesicles at the sarcolemma disruption sites (By similarity).
Short Description	Boster Bio Anti-Dysferlin Antibody (Catalog # A01234-1). Tested in WB applications. This antibody reacts with Human, Mouse.
Description	Boster Bio Anti-Dysferlin Antibody (Catalog # A01234-1). Tested in WB applications. This antibody reacts with Human, Mouse.
Tissue Specificity	Expressed in skeletal muscle, myoblast, myotube and in the syncytiotrophoblast (STB) of the placenta (at protein level). Ubiquitous. Highly expressed in skeletal muscle. Also found in heart, brain, spleen, intestine, placenta and at lower levels in liver, lung, kidney and pancreas.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-A01234-1-datasheet.pdf

BOS-A01234-1-safety-datasheet.pdf