Anti-ASPSCR1/Tug Antibody

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Polyclonal

ASPSCR1

Tug (Tether containing UBX domain for GLUT4), also known as ASPL, ASPSCR1, RCC17, UBXD9, UBXN9, was first identified as a chromosomal translocation partner for TFE3 in patients with Alveolar soft part sarcoma and contains an UBX-like domain in its C-terminal region. Tug is found to tether GLUT4 in intracellular vesicles and to release GLUT4 for cell surface translocation upon insulin stimulation . Stable Tug depletion or expression of a dominant negative form stimulates GLUT4 redistribution.
Ladanyi, M. et al. (2001) Oncogene 20, 48-57.
Bogan, J.S. et al. (2003) Nature 425, 727-33.
Yu, C. et al. (2007) J Biol Chem 282, 7710-22.

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1 mg/ml

Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface (By similarity). Enhances VCP methylation catalyzed by VCPKMT.

Boster Bio Anti-ASPSCR1/Tug Antibody (Catalog # A05168). Tested in WB applications. This antibody reacts with Human.

Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas.