Anti-ITPK1 Antibody

Rabbit IgG

45621 MW

Western Blot, 1:500 - 1:2000
ELISA, 1:10000
Not yet tested in other applications.

Inositol-tetrakisphosphate 1-kinase

PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Kinase that can phosphorylate various inositol polyphosphate such as Ins (3, 4, 5, 6)P4 or Ins (1, 3, 4)P3. Phosphorylates Ins (3, 4, 5, 6)P4 at position 1 to form Ins (1, 3, 4, 5, 6)P5. This reaction is thought to have regulatory importance, since Ins (3, 4, 5, 6)P4 is an inhibitor of plasma membrane Ca (2+)-activated Cl (-) channels, while Ins (1, 3, 4, 5, 6)P5 is not. Also phosphorylates Ins (1, 3, 4)P3 on O-5 and O-6 to form Ins (1, 3, 4, 6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins (1, 3, 4, 5)P4 and Ins (1, 3, 4, 6)P4 to Ins (1, 3, 4)P3, and Ins (1, 3, 4, 5, 6)P5 to Ins (3, 4, 5, 6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins (1, 3, 4, 5)P4 and Ins (1, 3, 4, 6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.

Boster Bio Anti-ITPK1 Antibody (Catalog# A09106). Tested in WB, ELISA applications. This antibody reacts with Human, Mouse.