Anti-Human CD11b ITGAM Monoclonal Antibody iFluor647 Conjugated, Flow Validated

Monoclonal Antibodies, Primary Antibodies

Store at 2-8°C. Avoid repeated freeze-thaw cycles.

Liquid, in PBS, pH7.2, <0.09% NaN3 and 0.2% (w/v) BSA

User needs to optimize the dilution ratio for this antibody.

Integrin alpha-M

PBS pH 7.2, 0.2% (w/v) BSA, 0.09% (w/v) sodium azide

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity).

Boster Bio Anti-Human CD11b ITGAM Monoclonal Antibody iFluor647 Conjugated, Flow Validated (Catalog# FC00144-iFluor647). Tested in Flow Cytometry application(s). This antibody reacts with Human.

Predominantly expressed in monocytes and granulocytes (PubMed:1346576). Expressed in neutrophils (at protein level) (PubMed:21193407).