Anti-Human CD8 Cd8a Monoclonal Antibody mFluor540 Conjugated, Flow Validated

Monoclonal Antibodies, Primary Antibodies

Store at 2-8°C. Avoid repeated freeze-thaw cycles.

Liquid, in PBS, pH7.2, <0.09% NaN3 and 0.2% (w/v) BSA

User needs to optimize the dilution ratio for this antibody.

T-cell surface glycoprotein CD8 alpha chain

PBS pH 7.2, 0.2% (w/v) BSA, 0.09% (w/v) sodium azide

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK- cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.

Boster Bio Anti-Human CD8 Cd8a Monoclonal Antibody mFluor540 Conjugated, Flow Validated (Catalog# FC02236-mFluor540). Tested in Flow Cytometry application(s). This antibody reacts with Human.