Anti-human CD10 MME Monoclonal Antibody Biotin Conjugated, Flow Validated

Store at 2-8°C. Avoid repeated freeze-thaw cycles.

Monoclonal

MME

CD10, also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), Neprilysin, or common acute lymphoblastic leukemia antigen (CALLA), is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably theamyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease. This gene is localized to human chromosome 3 by study of somatic cell hybrids and regionalized the location to 3q21-q27 by in situ hybridization. By cDNA transfection analysis, CD10 is confirmed as a functional neutral endopeptidase of the type that has previously been called enkephalinase. CD10 has also been called atriopeptidase. Atriopeptidase specifically degrades atrial natriuretic factor. A specific enzyme inhibitor was developed and reported that it had effects similar to those of low-dose ANF infusion. These effects include diuresis, natriuresis, vasodilatation, and suppression of the renin-angiotensin-aldosterone system.

PBS pH 7.2, 0.09% (w/v) sodium azide

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Neprilysin

Cell membrane; Single-pass type II membrane protein.

Boster Bio Anti-human CD10 MME Monoclonal Antibody Biotin Conjugated, Flow Validated (Catalog# FC04065-Biotin). Tested in Flow Cytometry application(s). This antibody reacts with Human.