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Anti-Progesterone Receptor (Marker of Progestin Dependence) PGR Monoclonal Antibody

Anti-Progesterone Receptor (Marker of Progestin Dependence) PGR Monoclonal Antibody

Item no.	BOS-M00541
Manufacturer	Boster
Amount	100 ug
Category	Oncology Food Safety Hormones Antibodies Immunohistochemistry Primary Antibodies By Organ Breast Cancer
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IHC
Clone	PR501
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Progesterone receptor;PR;Nuclear receptor subfamily 3 group C member 3;PGR;NR3C3;
Available
Manufacturer - Category	Primary Antibodies, Monoclonal Antibodies, 2279
Storage Conditions	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Observed Molecular Weight	98981 MW
Clonality	Monoclonal
Application Details	Western Blot (1-2ug/ml for 2 hours at Room Temp) Immunohistochemistry (Formalin-fixed) (1-2ug/ml) (Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes) Optimal dilution for a specific application should be determined.
Manufacturer - Gene Name	PGR
Gene Full Name	Progesterone receptor
Background	This monoclonal antibody is specific to progesterone receptor and shows minimal cross-reaction with other members of the family. Progesterone receptor is expressed as two major isoforms, PR-A (81kDa) and PR-B (116kDa). Expression of PgR has been suggested to reflect a intact estrogen regulatory machinery and therefore, predict better clinical response to endocrine therapy than ER alone.
Immunogen	Recombinant human Progesterone Receptor protein
Contents	Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Purification	200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.
Concentration	Purified antibody with BSA and azide at 200ug/ml
Manufacturer - Research Category	Cancer, Domain Families, Endocrine System, Epigenetics and Nuclear Signaling, Neuroscience, Nuclear Hormone Receptors, Nuclear Receptors, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, Transcription, Tumor Biomarkers, Zinc Finger
Protein Function	The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.
Subcellular Localization	Nucleus
Short Description	Boster Bio Anti-Progesterone Receptor (Marker of Progestin Dependence) PGR Monoclonal Antibody (Catalog # M00541). Tested in WB, IHC applications. This antibody reacts with Human.
Description	Boster Bio Anti-Progesterone Receptor (Marker of Progestin Dependence) PGR Monoclonal Antibody (Catalog # M00541). Tested in WB, IHC applications. This antibody reacts with Human.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-M00541-datasheet.pdf

BOS-M00541-safety-datasheet.pdf