« Back
Home /
Anti-Human CASR DyLight® 550 conjugated Antibody(monoclonal, 11E9)

Anti-Human CASR DyLight® 550 conjugated Antibody(monoclonal, 11E9)

Item no.	BOS-M00574-Dyl550
Manufacturer	Boster
Amount	100 ug/vial
Category	Neuroscience Molecular Targets for Neuroscience Antibodies Flow Cytometry Primary Antibodies
Type	Antibody Primary
Format	Liquid
Applications	FC
Clone	11E9
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2b
Conjugate/Tag	DyLight 550
Sensitivity	>5000 cells
Citations	1. Coburn JW, Elangovan L, Goodman WG, Frazaõ JM (Dec 1999). "Calcium-sensing receptor and calcimimetic agents". Kidney International. Supplement 73: S52–8. 2. D'Souza-Li L (Aug 2006). "The calcium-sensing receptor and related diseases". Arquivos Brasileiros De Endocrinologia E Metabologia 50 (4): 628–39. 3. Pidasheva S, Canaff L, Simonds WF, Marx SJ, Hendy GN (Jun 2005). "Impaired cotranslational processing of the calcium-sensing receptor due to signal peptide missense mutations in familial hypocalciuric hypercalcemia". Human Molecular Genetics 14 (12): 1679–90.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Extracellular calcium-sensing receptor; CaR
Available
Specificity	No cross reactivity with other proteins.
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Mouse IgG2b
Storage Conditions	At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Observed Molecular Weight	39 kDa
Clonality	Monoclonal
Application Details	Flow Cytometry (Fixed), 1-3?g/1x10⁶ cells
Manufacturer - Gene Name	CASR
Gene Full Name	calcium sensing receptor
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.
Immunogen	E. coli-derived human CASR recombinant protein (Position: Q926-S1078). Human CASR shares 80.5% and 78.6% amino acid (aa) sequence identity with mouse and rat CASR, respectively.
Contents	Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Manufacturer - Research Category	Calcium Signaling, Cancer, Cofactors, Vitamins/Minerals, Cytoskeleton/ECM, Extracellular Matrix, G Protein Signaling, Growth Factors/Hormones, Lipid Signaling, Metabolism, Neuroscience, Neurotransmission, Pathways and Processes, Receptors / Channels, Signal Transduction, Signaling Pathway, Structures, Vitamins/Minerals
Protein Function	G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed:7759551). The G-protein- coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547).
Subcellular Localization	Cell membrane
Description	Boster Bio Anti-Human CASR DyLight® 550 conjugated Antibody (monoclonal, 11E9) catalog # M00574-Dyl550. Tested in Flow Cytometry applications. This antibody reacts with Human.
Tissue Specificity	Expressed in the temporal lobe, frontal lobe, parietal lobe, hippocampus, and cerebellum. Also found in kidney, lung, liver, heart, skeletal muscle, placenta.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-M00574-Dyl550-datasheet.pdf

BOS-M00574-Dyl550-safety-datasheet.pdf