« Back
Home /
Anti-TSH-Receptor, B-Chain (Thyroid Marker) Monoclonal Antibody

Anti-TSH-Receptor, B-Chain (Thyroid Marker) Monoclonal Antibody

Item no.	BOS-M00576
Manufacturer	Boster
Amount	100 ug
Category	Oncology Antibodies Immunohistochemistry Immunofluorescence Primary Antibodies By Organ Thyroid Cancer
Type	Antibody Monoclonal
Format	Liquid
Applications	FC, IF, IHC
Clone	SPM222
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a Kappa
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Thyrotropin receptor;Thyroid-stimulating hormone receptor;TSH-R;TSHR;LGR3;
Available
Manufacturer - Category	Primary Antibodies, Monoclonal Antibodies, 2279
Storage Conditions	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Observed Molecular Weight	86830 MW
Clonality	Monoclonal
Application Details	Flow Cytometry (1-2ug/million cells) Immunofluorescence (1-2ug/ml) Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris buffer with 1mM EDTA, pH 8.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
Manufacturer - Gene Name	TSHR
Gene Full Name	Thyrotropin receptor
Background	Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Grave' s disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.
Immunogen	Recombinant human TSHR, B-Chain protein
Contents	Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Purification	200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.
Concentration	Purified antibody with BSA and azide at 200ug/ml
Manufacturer - Research Category	Endocrine System, Growth Factors/Hormones, Neuroscience, Signal Transduction
Protein Function	Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).
Subcellular Localization	Cell Surface and Cytoplasmic
Short Description	Boster Bio Anti-TSH-Receptor, B-Chain (Thyroid Marker) Monoclonal Antibody (Catalog # M00576). Tested in Flow Cytometry, IF, IHC applications. This antibody reacts with Human.
Description	Boster Bio Anti-TSH-Receptor, B-Chain (Thyroid Marker) Monoclonal Antibody (Catalog # M00576). Tested in Flow Cytometry, IF, IHC applications. This antibody reacts with Human.
Tissue Specificity	Expressed in the thyroid.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-M00576-datasheet.pdf

BOS-M00576-safety-datasheet.pdf