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Anti-Human Emerin DyLight® 488 conjugated EMD Antibody(monoclonal, 5A10)

Anti-Human Emerin DyLight® 488 conjugated EMD Antibody(monoclonal, 5A10)

Item no.	BOS-M00714-Dyl488
Manufacturer	Boster
Amount	100 ug/vial
Category	Metabolism Cholesterol & Lipid Metabolism Antibodies Flow Cytometry Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	FC
Clone	5A10
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
Conjugate/Tag	DyLight 488
Sensitivity	>5000 cells
Citations	1. Entrez Gene: EMD emerin (Emery–Dreifuss muscular dystrophy). 2. Lammerding, J; Hsiao, J; Schulze, PC; Kozlov, S; Stewart, CL; Lee, RT (29 August 2005). Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells. The Journal of Cell Biology. 170 (5): 781–91. 3. Nagano A, Koga R, Ogawa M, Kurano Y, Kawada J, Okada R, Hayashi YK, Tsukahara T, Arahata K (Mar 1996). Emerin deficiency at the nuclear membrane in patients with Emery–Dreifuss muscular dystrophy. Nature Genetics. 12 (3): 254–9.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Emerin,EMD,EDMD,STA
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Observed Molecular weight	39 kDa
Clonality	Monoclonal
Application Details	Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells
Gene Name	EMD
Gene Full Name	emerin
Manufacturer - Specificity	No cross reactivity with other proteins.
Immunogen	A synthetic peptide corresponding to a sequence at the N-terminus of human Emerin, different from the related mouse sequence by eight amino acids, and from the related rat sequence by nine amino acids.
Contents	Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
Concentration	0.5mg/ml
Manufacturer - Research Category	Biochemicals, Chemical Type, Neuroscience, Neurotransmission, Obesity, Receptors / Channels
Protein Function	Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta- catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.
Subcellular Localization	Nucleus inner membrane.
Description	Boster Bio Anti-Human Emerin DyLight® 488 conjugated EMD Antibody (monoclonal, 5A10) catalog # M00714-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.
Tissue Specificity	Skeletal muscle, heart, colon, testis, ovary and pancreas.
Manufacturer - Cross Reactivity	No cross-reactivity with other proteins.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-M00714-Dyl488-datasheet.pdf

BOS-M00714-Dyl488-safety-datasheet.pdf