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Anti-CD35 / CR1 (Follicular Dendritic Cell Marker) Monoclonal Antibody

Anti-CD35 / CR1 (Follicular Dendritic Cell Marker) Monoclonal Antibody

Item no.	BOS-M01022
Manufacturer	Boster
Amount	100 ug
Category	Neuroscience Neuroinflammation Antibodies Immunohistochemistry Immunofluorescence Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	FC, IF, IHC
Clone	SPM554
Specific against	Human (Homo sapiens), Monkey (Cynomolgus, Simian), Rhesus macaque
Host	Mouse
Isotype	IgG1 Kappa
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Complement receptor type 1;C3b/C4b receptor;CD35;CR1;C3BR;
Available
Specificity	Human,Baboon,Cynomolgus monkey,Rhesus monkey
Manufacturer - Category	Primary Antibodies, Monoclonal Antibodies, 2279
Storage Conditions	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Observed Molecular Weight	223663 MW
Clonality	Monoclonal
Application Details	Flow Cytometry (1-2ug/million cells) Immunofluorescence (1-2ug/ml) Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes) Optimal dilution for a specific application should be determined.
Manufacturer - Gene Name	CR1
Gene Full Name	Complement receptor type 1
Background	Recognizes a protein of 210-220kDa, which is identified as the complement receptor 1 (CR1)/CD35. This monoclonal antibody is specific for a site in CR1 that is distal from the C3b-binding site, so that it is unable to block CR1 activity. This monoclonal antibody is highly specific to CR1 and shows no cross-reaction with CR2. The primary function of CR1 is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. The Knops blood group system is a system of antigens located on this protein.Follicular dendritic cells (FDC) are restricted to the B-cell regions of secondary lymphoid follicles. They are CD21+/CD35+/CD1a-. This monoclonal antibody labels follicular dendritic cells and follicular dendritic cell sarcoma.
Immunogen	Intact human monocytes
Contents	Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Purification	200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.
Concentration	Purified antibody with BSA and azide at 200ug/ml
Protein Function	Mediates cellular binding of particles and immune complexes that have activated complement.
Subcellular Localization	Cell surface
Short Description	Boster Bio Anti-CD35 / CR1 (Follicular Dendritic Cell Marker) Monoclonal Antibody (Catalog # M01022). Tested in Flow Cytometry, IF, IHC applications. This antibody reacts with Human, Baboon, Cynomolgus monkey, Rhesus monkey.
Description	Boster Bio Anti-CD35 / CR1 (Follicular Dendritic Cell Marker) Monoclonal Antibody (Catalog # M01022). Tested in Flow Cytometry, IF, IHC applications. This antibody reacts with Human, Baboon, Cynomolgus monkey, Rhesus monkey.
Tissue Specificity	Present on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-M01022-datasheet.pdf

BOS-M01022-safety-datasheet.pdf