Anti-Somatostatin Receptor 2 SSTR2 Rabbit Monoclonal Antibody

Rabbit Monoclonal Antibodies

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

41333 MW

WB 1:1000-1:2000
IHC 1:50-1:200
IP 1:50

Somatostatin receptor type 2

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5 mg/ml BSA.

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Cancer, Cancer Metabolism, Endocrine Metabolism, Hormone Biosynthesis, Metabolic Signaling Pathway, Metabolism, More Gpcr, Neurology Process, Neuropeptides, Neuroscience, Neurotransmission, Neurotransmitter, Pathways and Processes, Receptors / Channels

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

Boster Bio Anti-Somatostatin Receptor 2 SSTR2 Rabbit Monoclonal Antibody catalog # M01689. Tested in WB, IHC, IP applications. This antibody reacts with Human, Mouse, Rat.