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Anti-TGF-alpha (Transforming Growth Factor alpha) Monoclonal Antibody

Anti-TGF-alpha (Transforming Growth Factor alpha) Monoclonal Antibody

Item no.	BOS-M01779
Manufacturer	Boster
Amount	100 ug
Category	Oncology Neuroscience Neural Signaling Antibodies By Cell Type Carcinoma Immunohistochemistry Immunofluorescence Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	FC, IF, IHC
Clone	TG86 + P/T1
Specific against	Human (Homo sapiens), Rabbit (Oryctolagus cuniculus), Zebrafish (Danio rerio)
Host	Mouse
Isotype	IgG1 Kappa
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Protransforming growth factor alpha;Transforming growth factor alpha;TGF-alpha;EGF-like TGF;ETGF;TGF type 1;TGFA;
Available
Manufacturer - Category	Primary Antibodies, Monoclonal Antibodies, 2279
Manufacturer - Isotype	IgG1, kappa + IgG1, kappa
Storage Conditions	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Observed Molecular Weight	17006 MW
Clonality	Monoclonal
Application Details	Flow Cytometry (1-2ug/million cells) Immunofluorescence (1-2ug/ml) Immunohistochemistry (Formalin-fixed) (2-4ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes) Optimal dilution for a specific application should be determined.
Manufacturer - Gene Name	TGFA
Gene Full Name	Protransforming growth factor alpha
Background	This antibody reacts with the TGF alpha and shows no cross-reaction with EGF and the neuropeptide synenkephalin. The staining with This monoclonal antibody is completely blocked by the peptide used for raising this antibody. TGF (aa50) is a growth factor with 33% homology to EGF, binds to EGFR, activates tyrosine phosphorylation of the receptor, and stimulates cell proliferation. It plays a role in tumor initiation by inducing the reversible transformed phenotype.
Immunogen	A 10-amino acid synthetic peptide (aa34-43; PPVAAAVVSH) from human TGFα (TG86 & P/T1)
Contents	Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA at 1.0mg/ml.
Purification	200ug/ml of antibody purified by Protein L.
Concentration	Purified antibody with BSA and azide at 200ug/ml
Manufacturer - Research Category	Angiogenesis, Cancer, Cardiovascular, Growth Factors, Growth Factors/Hormones, Invasion/Microenvironment, Signal Transduction
Protein Function	TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
Subcellular Localization	Cytoplasmic and Extracellular (secreted)
Short Description	Boster Bio Anti-TGF-alpha (Transforming Growth Factor alpha) Monoclonal Antibody (Catalog # M01779). Tested in Flow Cytometry, IF, IHC applications. This antibody reacts with Human, Rabbit, Zebrafish.
Description	Boster Bio Anti-TGF-alpha (Transforming Growth Factor alpha) Monoclonal Antibody (Catalog # M01779). Tested in Flow Cytometry, IF, IHC applications. This antibody reacts with Human, Rabbit, Zebrafish.
Tissue Specificity	Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-M01779-datasheet.pdf

BOS-M01779-safety-datasheet.pdf