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Anti-Alpha Actinin-4 ACTN4 Rabbit Monoclonal Antibody, Clone#RM287

Anti-Alpha Actinin-4 ACTN4 Rabbit Monoclonal Antibody, Clone#RM287

Item no.	BOS-M01975-1
Manufacturer	Boster
Amount	100 ul
Category	Neuroscience Neural Lineage Markers Antibodies Immunohistochemistry Western Blot Primary Antibodies Cytoskeleton Markers
Type	Antibody Primary
Format	Liquid
Applications	WB, IHC
Clone	RM287
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Alpha-actinin-4 ;Non-muscle alpha-actinin 4 ;ACTN4 ;
Available
Manufacturer - Category	Primary Antibodies, Monoclonal Antibodies, Rabbit Monoclonal Antibodies, 2279
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	104854 MW
Clonality	Monoclonal
Application Details	Immunohistochemistry (IHC): 1:100-1:200 dilution WB: 1:1000-1:2000 dilution.
Manufacturer - Gene Name	ACTN4
Gene Full Name	Alpha-actinin-4
Immunogen	A peptide corresponding to the N-terminus of human alpha-Actinin-4
Contents	50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purification	Protein A affinity purified from an animal origin-free culture supernatant
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Manufacturer - Research Category	Invasion/Microenvironment, Metabolism, Metabolism Processes, Microfilaments, Pathways and Processes, Response To Hypoxia, Signal Transduction
Protein Function	F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778).
Subcellular Localization	Nucleus. Cytoplasm. Cell junction. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Colocalizes with actin stress fibers. Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines (breast cancer cell line MCF-7, oral floor cancer IMC- 2, and bladder cancer KU-7).
Short Description	Boster Bio Anti-Alpha Actinin-4 ACTN4 Rabbit Monoclonal Antibody, Clone#RM287 (Catalog # M01975-1). Tested in IHC, WB applications. This antibody reacts with Human.
Description	Boster Bio Anti-Alpha Actinin-4 ACTN4 Rabbit Monoclonal Antibody, Clone#RM287 (Catalog # M01975-1). Tested in IHC, WB applications. This antibody reacts with Human.
Tissue Specificity	Widely expressed.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-M01975-1-datasheet.pdf

BOS-M01975-1-safety-datasheet.pdf