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Anti-p120-catenin Rabbit Monoclonal Antibody, Clone#RM353

Anti-p120-catenin Rabbit Monoclonal Antibody, Clone#RM353

Item no.	BOS-M02333-1
Manufacturer	Boster
Amount	100 ul
Category	Neuroscience Neural Adhesion Molecules Antibodies Immunohistochemistry Immunoprecipitation Western Blot Immunofluorescence Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IHC
Clone	RM353
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Catenin delta-1;Cadherin-associated Src substrate;CAS;p120 catenin;p120 (ctn);p120 (cas);CTNND1;KIAA0384;
Available
Manufacturer - Category	Primary Antibodies, Monoclonal Antibodies, Rabbit Monoclonal Antibodies, 2279
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	108170 MW
Clonality	Monoclonal
Application Details	Immunohistochemistry (IHC): 1:1000-1:5000 dilution WB: 1:500-1:1000 dilution.
Manufacturer - Gene Name	CTNND1
Gene Full Name	Catenin delta-1
Immunogen	A peptide corresponding to the C-terminus of human p120 catenin (Catenin delta-1)
Contents	50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purification	Protein A affinity purified from an animal origin-free culture supernatant
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Manufacturer - Research Category	Actin, etc., Cytoplasmic, Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction, Signaling Pathways, Stem Cells
Protein Function	Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
Subcellular Localization	Cytoplasm. Nucleus. Cell membrane. Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts (PubMed:15240885, PubMed:17047063). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (PubMed:17047063). CDH1 enhances cell membrane localization (PubMed:15240885). Isoforms 4A and 1AB are excluded from the nucleus (PubMed:11896187).
Short Description	Boster Bio Anti-p120-catenin Rabbit Monoclonal Antibody, Clone#RM353 (Catalog # M02333-1). Tested in IHC, WB applications. This antibody reacts with Human.
Description	Boster Bio Anti-p120-catenin Rabbit Monoclonal Antibody, Clone#RM353 (Catalog # M02333-1). Tested in IHC, WB applications. This antibody reacts with Human.
Tissue Specificity	Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-M02333-1-datasheet.pdf

BOS-M02333-1-safety-datasheet.pdf