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Anti-VEGI (Vascular Endothelial Growth Inhibitor) TNFSF15 Monoclonal Antibody

Anti-VEGI (Vascular Endothelial Growth Inhibitor) TNFSF15 Monoclonal Antibody

Item no.	BOS-M02402-1
Manufacturer	Boster
Amount	100 ug
Category	Antibodies Cell Biology Cell Status Apoptosis Immunohistochemistry Immunofluorescence Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	IHC
Clone	VEGI/1283
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Tumor necrosis factor ligand superfamily member 15;TNF ligand-related molecule 1;Vascular endothelial cell growth inhibitor;Tnfsf15;Tl1, Vegi;
Available
Manufacturer - Category	Primary Antibodies, Monoclonal Antibodies, 2279
Storage Conditions	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Observed Molecular Weight	27723 MW
Clonality	Monoclonal
Application Details	Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes) Optimal dilution for a specific application should be determined.
Manufacturer - Gene Name	TNFSF15
Gene Full Name	Tumor necrosis factor ligand superfamily member 15
Background	VEGI is an anti-angiogenic cytokine that belongs to tumor necrosis factor superfamily, member 15 (TNFSF15). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of VEGI has been reported as a marker of poor prognosis in breast cancer.
Immunogen	Recombinant human VEGI fragment
Contents	Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Purification	200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.
Concentration	Purified antibody with BSA and azide at 200ug/ml
Manufacturer - Research Category	Angiogenesis, Cardiovascular, Cytokines, Immunology, Innate Immunity, TNF Superfamily
Protein Name	Tumor necrosis factor ligand superfamily member 15 (TNFSF15)
Protein Function	Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis (By similarity). Promotes splenocyte alloactivation.
Subcellular Localization	Cell Surface and Secreted
Short Description	Boster Bio Anti-VEGI (Vascular Endothelial Growth Inhibitor) TNFSF15 Monoclonal Antibody (Catalog # M02402-1). Tested in IHC applications. This antibody reacts with Human.
Description	Boster Bio Anti-VEGI (Vascular Endothelial Growth Inhibitor) TNFSF15 Monoclonal Antibody (Catalog # M02402-1). Tested in IHC applications. This antibody reacts with Human.
Tissue Specificity	Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-M02402-1-datasheet.pdf

BOS-M02402-1-safety-datasheet.pdf