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Anti-Desmoglein-3 (Squamous Cell Marker) DSG3 Monoclonal Antibody

Anti-Desmoglein-3 (Squamous Cell Marker) DSG3 Monoclonal Antibody

Item no.	BOS-M03093
Manufacturer	Boster
Amount	100 ug
Category	Oncology Antibodies Immunohistochemistry Immunofluorescence Primary Antibodies By Organ Skin Cancer
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IHC
Clone	DSG3/1535
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Desmoglein-3;130 kDa pemphigus vulgaris antigen;PVA;Cadherin family member 6;DSG3;CDHF6;
Available
Manufacturer - Category	Primary Antibodies, Monoclonal Antibodies, 2279
Storage Conditions	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Observed Molecular Weight	107533 MW
Clonality	Monoclonal
Application Details	Western Blot (1-2ug/ml) Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes) Optimal dilution for a specific application should be determined.
Manufacturer - Gene Name	DSG3
Gene Full Name	Desmoglein-3
Background	Recognizes a protein of 130kDa, identified as Desmoglein-3 (DSG3). This monoclonal antibody is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis.
Immunogen	Recombinant human DSG3 extracellular protein fragment
Contents	Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Purification	200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.
Concentration	Purified antibody with BSA and azide at 200ug/ml
Manufacturer - Research Category	Cadherins, Cell Adhesion, Cytoskeleton/ECM, Extracellular Matrix, Signal Transduction, Structures
Protein Function	Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Subcellular Localization	Cell Surface
Short Description	Boster Bio Anti-Desmoglein-3 (Squamous Cell Marker) DSG3 Monoclonal Antibody (Catalog # M03093). Tested in WB, IHC applications. This antibody reacts with Human.
Description	Boster Bio Anti-Desmoglein-3 (Squamous Cell Marker) DSG3 Monoclonal Antibody (Catalog # M03093). Tested in WB, IHC applications. This antibody reacts with Human.
Tissue Specificity	Epidermis, tongue, tonsil, esophagus and carcinomas.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-M03093-datasheet.pdf

BOS-M03093-safety-datasheet.pdf