« Back
Home /
Anti-Smac/Diablo Rabbit Monoclonal Antibody, Clone#RM271

Anti-Smac/Diablo Rabbit Monoclonal Antibody, Clone#RM271

Item no.	BOS-M03790-2
Manufacturer	Boster
Amount	100 ul
Category	Antibodies Cell Biology Cell Status Apoptosis Flow Cytometry Immunohistochemistry Immunoprecipitation Western Blot Immunofluorescence Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	WB, IHC
Clone	RM271
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Diablo homolog, mitochondrial;Direct IAP-binding protein with low pI;Second mitochondria-derived activator of caspase;Smac;DIABLO;SMAC;
Available
Manufacturer - Category	Primary Antibodies, Monoclonal Antibodies, Rabbit Monoclonal Antibodies, 2279
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	27131 MW
Clonality	Monoclonal
Application Details	Immunohistochemistry (IHC): 1:500-1:1000 dilution WB: 1:1000-1:2000 dilution.
Manufacturer - Gene Name	DIABLO
Gene Full Name	Diablo homolog, mitochondrial
Immunogen	A peptide corresponding to the C-terminus of human Smac (Diablo homolog, mitochondrial).
Contents	50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purification	Protein A affinity purified from an animal origin-free culture supernatant
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Manufacturer - Research Category	Apoptosis, Cancer, Cell Biology, Cell Death, Invasion/Microenvironment, Metabolism, Metabolism Processes, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Receptors
Protein Function	Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis- inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
Subcellular Localization	Mitochondrion. Released into the cytosol when cells undergo apoptosis.
Short Description	Boster Bio Anti-Smac/Diablo Rabbit Monoclonal Antibody, Clone#RM271 (Catalog # M03790-2). Tested in IHC, WB applications. This antibody reacts with Human.
Description	Boster Bio Anti-Smac/Diablo Rabbit Monoclonal Antibody, Clone#RM271 (Catalog # M03790-2). Tested in IHC, WB applications. This antibody reacts with Human.
Tissue Specificity	Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-M03790-2-datasheet.pdf

BOS-M03790-2-safety-datasheet.pdf