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Anti-Cytokeratin 15 (KRT15) (Basal Cell Marker) Monoclonal Antibody

Anti-Cytokeratin 15 (KRT15) (Basal Cell Marker) Monoclonal Antibody

Item no.	BOS-M06791
Manufacturer	Boster
Amount	100 ug
Category	Antibodies Cell Biology Cytoskeleton Immunohistochemistry Immunofluorescence Primary Antibodies Intermediate filaments
Type	Antibody Monoclonal
Format	Liquid
Applications	IHC
Clone	KRT15/1699
Specific against	Human (Homo sapiens), Rat (Rattus norvegicus), Cow (Bos taurus)
Host	Mouse
Isotype	IgG2a Kappa
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Keratin, type I cytoskeletal 15;Cytokeratin-15;CK-15;Keratin-15;K15;KRT15;KRTB;
Available
Manufacturer - Category	Primary Antibodies, Monoclonal Antibodies, 2279
Storage Conditions	Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Observed Molecular Weight	49212 MW
Clonality	Monoclonal
Application Details	Immunohistochemistry (Formalin-fixed) (0.1-0.2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes) Optimal dilution for a specific application should be determined.
Manufacturer - Gene Name	KRT15
Gene Full Name	Keratin, type I cytoskeletal 15
Background	Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a diagnosis difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.
Immunogen	Recombinant human KRT15 protein
Contents	Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Purification	200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.
Concentration	Purified antibody with BSA and azide at 200ug/ml
Manufacturer - Research Category	Class I, Cytoskeleton, Cytoskeleton/ECM, Intermediate Filaments, Signal Transduction
Subcellular Localization	Cytoplasmic
Short Description	Boster Bio Anti-Cytokeratin 15 (KRT15) (Basal Cell Marker) Monoclonal Antibody (Catalog # M06791). Tested in IHC applications. This antibody reacts with Human, Rat, Cow.
Description	Boster Bio Anti-Cytokeratin 15 (KRT15) (Basal Cell Marker) Monoclonal Antibody (Catalog # M06791). Tested in IHC applications. This antibody reacts with Human, Rat, Cow.
Tissue Specificity	Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-M06791-datasheet.pdf

BOS-M06791-safety-datasheet.pdf