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Anti-Phospho-Munc18-1 (Ser241) STXBP1 Antibody

Anti-Phospho-Munc18-1 (Ser241) STXBP1 Antibody

Item no.	BOS-P02351
Manufacturer	Boster
Amount	100 ul
Category	Neuroscience Molecular Targets for Neuroscience Neural Signaling Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody
Format	Liquid
Applications	WB, IHC
Specific against	Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	FLJ37475 antibody, Munc 18 1 antibody, Munc 18a antibody, MUNC18 1 antibody, N-Sec1 antibody, Neuronal SEC1 antibody, NSec1 antibody, p67 antibody, Protein unc-18 homolog 1 antibody, Protein unc-18 homolog A antibody, Rb sec1 antibody, RBSEC1 antibody, STXB1_HUMAN antibody, STXBP1 antibody, Syntaxin binding protein 1 antibody, Syntaxin-binding protein 1 antibody, Unc 18 homolog antibody, Unc 18A antibody, Unc-18A antibody, Unc18 1 antibody, UNC18 antibody, Unc18-1 antibody
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. After date of receipt, stable for at least 1 year at -20°C.
Observed Molecular Weight	67569 MW
Clonality	Polyclonal
Application notes	Specific for endogenous levels of the ~65 kDa Munc18-1 protein phosphorylated at Ser241. Immunolabeling is completely eliminated by treatment with ?-phosphatase.
Application Details	WB: 1:1000 IHC: 1:500
Manufacturer - Gene Name	STXBP1
Gene Full Name	Syntaxin-binding protein 1
Background	Munc-18 (mammalian homologue of Unc-18) is a protein that is thought to be involved in regulating exocytosis due, at least in part, to it ability to bind syntaxin (Ciufo et al., 2005). Munc18-1 is a neuron-specific member of the Sec1/Munc18 protein family that binds to syntaxin1A and is thought to stabilize the complex (Liu et al., 2004). The function of Munc18-1 is thought to be regulated by phosphorylation.
Immunogen	Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser241 of mouse Munc18-1, conjugated to keyhole limpet hemocyanin (KLH). Immunogen species is Mouse.
Contents	10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Purification	Prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho and non-phosphopeptide affinity columns.
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Phospho Site	Phosphorylated, Ser241
Manufacturer - Research Category	Cancer, Cancer Metabolism, Cell Type Marker, Energy Transfer Pathways, Integration Of Energy, Integration Of Energy Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Neuron Marker, Neuroscience, Neurotransmission, Pathways and Processes, Secretory Vesicles, Synapse Marker
Protein Name	Syntaxin-binding protein 1
Protein Function	May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
Subcellular Localization	Cytoplasm, cytosol. Membrane; Peripheral membrane protein.
Short Description	Boster Bio Anti-Phospho-Munc18-1 (Ser241) STXBP1 Antibody (Catalog # P02351). Tested in WB, IHC applications. This antibody reacts with Mouse, Rat.
Description	Boster Bio Anti-Phospho-Munc18-1 (Ser241) STXBP1 Antibody (Catalog # P02351). Tested in WB, IHC applications. This antibody reacts with Mouse, Rat.
Tissue Specificity	Brain and spinal cord. Highly enriched in axons.
Predicted Reactivity	Bovine, Canine, Chicken, Human, Primate, Sheep

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BOS-P02351-datasheet.pdf

BOS-P02351-safety-datasheet.pdf