Anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) Kcnc1 Antibody

Primary Antibodies

65857 MW

Specific for endogenous levels of the ~100 kDa Kv3.1 voltage-gated potassium channel protein phosphorylated at Ser503.

KCNC1

Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999). Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Neuroscience, Neurotransmission, Potassium Channels, Receptors / Channels

Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed:10482766, PubMed:14679187). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well (PubMed:10482766, PubMed:14679187). Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons (PubMed:10482766).

Boster Bio Anti-Phospho-Potassium Channel, Voltage Gated, Kv3.1-Subunit (Ser503) Kcnc1 Antibody (Catalog # P06871). Tested in WB, IHC, ICC applications. This antibody reacts with Hamster, Mouse, Rat.

Expressed in globus pallidal neurons of the basal ganglia (at protein level) (PubMed:10482766). Brain (PubMed:1378392).